ST14 (ST14 transmembrane serine protease matriptase)

2003-02-01  

Identity

HGNC
ST14
LOCATION
11q24.3
LOCUSID
6768
ALIAS
ARCI11,CAP3,HAI,MT-SP1,MTSP1,PRSS14,SNC19,TADG15,TMPRSS14
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6768
MIM: 606797
HGNC: 11344
Ensembl: ENSG00000149418

Variants:

dbSNP: 6768
ClinVar: 6768
TCGA: ENSG00000149418
COSMIC: ST14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149418ENST00000278742Q9Y5Y6

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Developmental BiologyREACTOMER-HSA-1266738
KeratinizationREACTOMER-HSA-6805567
Formation of the cornified envelopeREACTOMER-HSA-6809371

References

Pubmed IDYearTitleCitations
385471262024Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion.0
385471262024Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion.0
350202742022Role of the polycystic kidney disease domain in matriptase chaperone activity and localization of hepatocyte growth factor activator inhibitor-1.2
359504572022Environment-Sensitive Ectodomain Shedding of Epithin/PRSS14 Increases Metastatic Potential of Breast Cancer Cells by Producing CCL2.0
359640512022Novel mutations of the ABCA12, KRT1 and ST14 genes in three unrelated newborns showing congenital ichthyosis.6
350202742022Role of the polycystic kidney disease domain in matriptase chaperone activity and localization of hepatocyte growth factor activator inhibitor-1.2
359504572022Environment-Sensitive Ectodomain Shedding of Epithin/PRSS14 Increases Metastatic Potential of Breast Cancer Cells by Producing CCL2.0
359640512022Novel mutations of the ABCA12, KRT1 and ST14 genes in three unrelated newborns showing congenital ichthyosis.6
344189852021Gene-associated methylation status of ST14 as a predictor of survival and hormone receptor positivity in breast Cancer.2
344189852021Gene-associated methylation status of ST14 as a predictor of survival and hormone receptor positivity in breast Cancer.2
322419172020A JUN N-terminal kinase inhibitor induces ectodomain shedding of the cancer-associated membrane protease Prss14/epithin via protein kinase CβII.5
323262122020Matriptase Cleaves EpCAM and TROP2 in Keratinocytes, Destabilizing Both Proteins and Associated Claudins.13
324933242020Intramembrane proteolysis of an extracellular serine protease, epithin/PRSS14, enables its intracellular nuclear function.2
327619202020Proteolytic cleavage of Trop2 at Arg87 is mediated by matriptase and regulated by Val194.7
330948012020Insights into the regulation of the matriptase-prostasin proteolytic system.2

Citation

Dessen P

ST14 (ST14 transmembrane serine protease matriptase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42418/st14-(st14-transmembrane-serine-protease-matriptase)