STAR (steroidogenic acute regulatory protein)

2003-11-01  

Identity

HGNC
STAR
LOCATION
8p11.23
LOCUSID
6770
ALIAS
STARD1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6770
MIM: 600617
HGNC: 11359
Ensembl: ENSG00000147465

Variants:

dbSNP: 6770
ClinVar: 6770
TCGA: ENSG00000147465
COSMIC: STAR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147465ENST00000276449P49675
ENSG00000147465ENST00000276449Q6IBK0
ENSG00000147465ENST00000521236E5RH12
ENSG00000147465ENST00000522050H0YB94

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
3500
4000
4500
5000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ovarian steroidogenesisKEGGhsa04913
Ovarian steroidogenesisKEGGko04913
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Metabolism of steroid hormonesREACTOMER-HSA-196071
Pregnenolone biosynthesisREACTOMER-HSA-196108
Aldosterone synthesis and secretionKEGGhsa04925
Aldosterone synthesis and secretionKEGGko04925

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
174337722007Steroidogenic acute regulatory protein (StAR), a novel mitochondrial cholesterol transporter.95
192310102009Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH.94
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
190015232009Prostaglandin E2 via steroidogenic factor-1 coordinately regulates transcription of steroidogenic genes necessary for estrogen synthesis in endometriosis.55
182501662008Steroidogenic activity of StAR requires contact with mitochondrial VDAC1 and phosphate carrier protein.43
192712492009Extended tracts of homozygosity identify novel candidate genes associated with late-onset Alzheimer's disease.43
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
186361242008Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.32
157772082005Regulation of the steroidogenic acute regulatory protein expression: functional and physiological consequences.31

Citation

Dessen P

STAR (steroidogenic acute regulatory protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42427/star-(steroidogenic-acute-regulatory-protein)