Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6775
MIM: 600558
HGNC: 11365
Ensembl: ENSG00000138378
Variants:
dbSNP: 6775
ClinVar: 6775
TCGA: ENSG00000138378
COSMIC: STAT4
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA134992438 | CAMK1D | Gene | Pathway | associated | |||
| PA24684 | AKT1 | Gene | Pathway | associated | |||
| PA24685 | AKT2 | Gene | Pathway | associated | |||
| PA24686 | AKT3 | Gene | Pathway | associated | |||
| PA248 | NFKB1 | Gene | Pathway | associated | |||
| PA26048 | CAMK1 | Gene | Pathway | associated | |||
| PA26049 | CAMK1G | Gene | Pathway | associated | |||
| PA27749 | ELK1 | Gene | Pathway | associated | |||
| PA28212 | FOS | Gene | Pathway | associated | |||
| PA283 | MAPK8 | Gene | Pathway | associated | |||
| PA296 | RELA | Gene | Pathway | associated | |||
| PA29988 | JAK1 | Gene | Pathway | associated | |||
| PA30006 | JUN | Gene | Pathway | associated | |||
| PA30616 | MAPK1 | Gene | Pathway | associated | |||
| PA30622 | MAPK3 | Gene | Pathway | associated | |||
| PA31353 | MYC | Gene | Pathway | associated | |||
| PA31600 | NFKB2 | Gene | Pathway | associated | |||
| PA337 | STAT3 | Gene | Pathway | associated | |||
| PA33759 | PRKCA | Gene | Pathway | associated | |||
| PA33761 | PRKCB | Gene | Pathway | associated | |||
| PA33766 | PRKCG | Gene | Pathway | associated | |||
| PA338 | STAT5A | Gene | Pathway | associated | |||
| PA36042 | SP1 | Gene | Pathway | associated | |||
| PA36183 | STAT1 | Gene | Pathway | associated | |||
| PA36184 | STAT2 | Gene | Pathway | associated | |||
| PA36186 | STAT5B | Gene | Pathway | associated | |||
| PA443434 | Arthritis, Rheumatoid | Disease | ClinicalAnnotation | associated | PD | ||
| PA449515 | etanercept | Chemical | ClinicalAnnotation | associated | PD | ||
| PA90 | CAMK2A | Gene | Pathway | associated | |||
| PA91 | CAMK2B | Gene | Pathway | associated | |||
| PA92 | CAMK2D | Gene | Pathway | associated | |||
| PA93 | CAMK2G | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37932931 | 2024 | TOX, TWIST1, STAT4, and SATB1 protein expressions in early-stage mycosis fungoides. | 0 |
| 38341034 | 2024 | STAT4 targets KISS1 to inhibit the oxidative damage, inflammation and neuronal apoptosis in experimental PD models by inactivating the MAPK pathway. | 0 |
| 38397230 | 2024 | STAT4 Gene Variant rs7574865 Is Associated with Rheumatoid Arthritis Activity and Anti-CCP Levels in the Western but Not in the Southern Population of Mexico. | 0 |
| 38429845 | 2024 | Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway. | 0 |
| 38774752 | 2024 | The Role of JAK-STAT-SOCS1 Axis in Tumorigenesis, Malignant Progression and Lymphatic Metastasis of Penile Cancer. | 0 |
| 37932931 | 2024 | TOX, TWIST1, STAT4, and SATB1 protein expressions in early-stage mycosis fungoides. | 0 |
| 38341034 | 2024 | STAT4 targets KISS1 to inhibit the oxidative damage, inflammation and neuronal apoptosis in experimental PD models by inactivating the MAPK pathway. | 0 |
| 38397230 | 2024 | STAT4 Gene Variant rs7574865 Is Associated with Rheumatoid Arthritis Activity and Anti-CCP Levels in the Western but Not in the Southern Population of Mexico. | 0 |
| 38429845 | 2024 | Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway. | 0 |
| 38774752 | 2024 | The Role of JAK-STAT-SOCS1 Axis in Tumorigenesis, Malignant Progression and Lymphatic Metastasis of Penile Cancer. | 0 |
| 36226497 | 2023 | Defective binding of ETS1 and STAT4 due to a mutation in the promoter region of THPO as a novel mechanism of congenital amegakaryocytic thrombocytopenia. | 1 |
| 36575804 | 2023 | Down-Regulation-Resistant STAT4 Risk Haplotype Contributes to Lupus Nephritis Through CD4+ T Cell Interferon-γ Production. | 0 |
| 36980810 | 2023 | Association of the STAT4 Gene rs7574865 Polymorphism with IFN-γ Levels in Patients with Systemic Lupus Erythematosus. | 0 |
| 37264954 | 2023 | STAT4, a potential predictor of prognosis, promotes CD8 T‑cell infiltration in ovarian serous carcinoma by inducing CCL5 secretion. | 0 |
| 37756335 | 2023 | Divergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammation. | 0 |
Citation
Dessen P
STAT4 (signal transducer and activator of transcription 4)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/42430/stat4-(signal-transducer-and-activator-of-transcription-4)
