STAT4 (signal transducer and activator of transcription 4)

2003-05-01 Affiliation

Identity

HGNC

STAT4

LOCATION

2q32.2

LOCUSID

6775

ALIAS

SLEB11

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6775
MIM: 600558
HGNC: 11365
Ensembl: ENSG00000138378

Variants:

dbSNP: 6775
ClinVar: 6775
TCGA: ENSG00000138378
COSMIC: STAT4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000138378	ENST00000358470	Q14765
ENSG00000138378	ENST00000392320	Q14765
ENSG00000138378	ENST00000409995	E9PG69
ENSG00000138378	ENST00000413064	C9JFG0
ENSG00000138378	ENST00000432798	C9JM11
ENSG00000138378	ENST00000450994	E9PBE2
ENSG00000138378	ENST00000647167	A0A2R8Y693

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Jak-STAT signaling pathway	KEGG	ko04630
Jak-STAT signaling pathway	KEGG	hsa04630
Hepatitis B	KEGG	hsa05161
Inflammatory bowel disease (IBD)	KEGG	hsa05321
Inflammatory bowel disease (IBD)	KEGG	ko05321
JAK-STAT signaling	KEGG	hsa_M00684
JAK-STAT signaling	KEGG	M00684
Th1 and Th2 cell differentiation	KEGG	ko04658
Th1 and Th2 cell differentiation	KEGG	hsa04658

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD
PA134992438	CAMK1D	Gene	Pathway	associated
PA24684	AKT1	Gene	Pathway	associated
PA24685	AKT2	Gene	Pathway	associated
PA24686	AKT3	Gene	Pathway	associated
PA248	NFKB1	Gene	Pathway	associated
PA26048	CAMK1	Gene	Pathway	associated
PA26049	CAMK1G	Gene	Pathway	associated
PA27749	ELK1	Gene	Pathway	associated
PA28212	FOS	Gene	Pathway	associated
PA283	MAPK8	Gene	Pathway	associated
PA296	RELA	Gene	Pathway	associated
PA29988	JAK1	Gene	Pathway	associated
PA30006	JUN	Gene	Pathway	associated
PA30616	MAPK1	Gene	Pathway	associated
PA30622	MAPK3	Gene	Pathway	associated
PA31353	MYC	Gene	Pathway	associated
PA31600	NFKB2	Gene	Pathway	associated
PA337	STAT3	Gene	Pathway	associated
PA33759	PRKCA	Gene	Pathway	associated
PA33761	PRKCB	Gene	Pathway	associated
PA33766	PRKCG	Gene	Pathway	associated
PA338	STAT5A	Gene	Pathway	associated
PA36042	SP1	Gene	Pathway	associated
PA36183	STAT1	Gene	Pathway	associated
PA36184	STAT2	Gene	Pathway	associated
PA36186	STAT5B	Gene	Pathway	associated
PA443434	Arthritis, Rheumatoid	Disease	ClinicalAnnotation	associated	PD
PA449515	etanercept	Chemical	ClinicalAnnotation	associated	PD
PA90	CAMK2A	Gene	Pathway	associated
PA91	CAMK2B	Gene	Pathway	associated
PA92	CAMK2D	Gene	Pathway	associated
PA93	CAMK2G	Gene	Pathway	associated

References

Pubmed ID	Year	Title	Citations
37932931	2024	TOX, TWIST1, STAT4, and SATB1 protein expressions in early-stage mycosis fungoides.	0
38341034	2024	STAT4 targets KISS1 to inhibit the oxidative damage, inflammation and neuronal apoptosis in experimental PD models by inactivating the MAPK pathway.	0
38397230	2024	STAT4 Gene Variant rs7574865 Is Associated with Rheumatoid Arthritis Activity and Anti-CCP Levels in the Western but Not in the Southern Population of Mexico.	0
38429845	2024	Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway.	0
38774752	2024	The Role of JAK-STAT-SOCS1 Axis in Tumorigenesis, Malignant Progression and Lymphatic Metastasis of Penile Cancer.	0
37932931	2024	TOX, TWIST1, STAT4, and SATB1 protein expressions in early-stage mycosis fungoides.	0
38341034	2024	STAT4 targets KISS1 to inhibit the oxidative damage, inflammation and neuronal apoptosis in experimental PD models by inactivating the MAPK pathway.	0
38397230	2024	STAT4 Gene Variant rs7574865 Is Associated with Rheumatoid Arthritis Activity and Anti-CCP Levels in the Western but Not in the Southern Population of Mexico.	0
38429845	2024	Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway.	0
38774752	2024	The Role of JAK-STAT-SOCS1 Axis in Tumorigenesis, Malignant Progression and Lymphatic Metastasis of Penile Cancer.	0
36226497	2023	Defective binding of ETS1 and STAT4 due to a mutation in the promoter region of THPO as a novel mechanism of congenital amegakaryocytic thrombocytopenia.	1
36575804	2023	Down-Regulation-Resistant STAT4 Risk Haplotype Contributes to Lupus Nephritis Through CD4+ T Cell Interferon-γ Production.	0
36980810	2023	Association of the STAT4 Gene rs7574865 Polymorphism with IFN-γ Levels in Patients with Systemic Lupus Erythematosus.	0
37264954	2023	STAT4, a potential predictor of prognosis, promotes CD8 T‑cell infiltration in ovarian serous carcinoma by inducing CCL5 secretion.	0
37756335	2023	Divergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammation.	0

Citation

Dessen P

STAT4 (signal transducer and activator of transcription 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42430/stat4-(signal-transducer-and-activator-of-transcription-4)