STAT5A (signal transducer and activator of transcription 5A)

2003-02-01 Affiliation

Identity

HGNC

STAT5A

LOCATION

17q21.2

LOCUSID

6776

ALIAS

MGF,STAT5

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6776
MIM: 601511
HGNC: 11366
Ensembl: ENSG00000126561

Variants:

dbSNP: 6776
ClinVar: 6776
TCGA: ENSG00000126561
COSMIC: STAT5A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000126561	ENST00000345506	P42229
ENSG00000126561	ENST00000345506	A0A384N5W4
ENSG00000126561	ENST00000444283	C9JVV6
ENSG00000126561	ENST00000546010	P42229
ENSG00000126561	ENST00000587646	K7EM17
ENSG00000126561	ENST00000588868	K7EK35
ENSG00000126561	ENST00000590726	K7EIF9
ENSG00000126561	ENST00000590949	P42229
ENSG00000126561	ENST00000590949	A0A384N5W4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
ErbB signaling pathway	KEGG	ko04012
Jak-STAT signaling pathway	KEGG	ko04630
Chronic myeloid leukemia	KEGG	ko05220
Acute myeloid leukemia	KEGG	ko05221
Non-small cell lung cancer	KEGG	ko05223
ErbB signaling pathway	KEGG	hsa04012
Jak-STAT signaling pathway	KEGG	hsa04630
Pathways in cancer	KEGG	hsa05200
Chronic myeloid leukemia	KEGG	hsa05220
Acute myeloid leukemia	KEGG	hsa05221
Non-small cell lung cancer	KEGG	hsa05223
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
Viral carcinogenesis	KEGG	hsa05203
Viral carcinogenesis	KEGG	ko05203
Hepatitis B	KEGG	hsa05161
Prolactin signaling pathway	KEGG	hsa04917
Prolactin signaling pathway	KEGG	ko04917
JAK-STAT signaling	KEGG	hsa_M00684
JAK-STAT signaling	KEGG	M00684
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
Signaling by FGFR in disease	REACTOME	R-HSA-1226099
Signaling by FGFR1 in disease	REACTOME	R-HSA-5655302
FGFR1 mutant receptor activation	REACTOME	R-HSA-1839124
Signaling by cytosolic FGFR1 fusion mutants	REACTOME	R-HSA-1839117
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-2 signaling	REACTOME	R-HSA-451927
Interleukin-3, 5 and GM-CSF signaling	REACTOME	R-HSA-512988
Interleukin-7 signaling	REACTOME	R-HSA-1266695
Growth hormone receptor signaling	REACTOME	R-HSA-982772
Prolactin receptor signaling	REACTOME	R-HSA-1170546
Signal Transduction	REACTOME	R-HSA-162582
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
Signaling by ERBB4	REACTOME	R-HSA-1236394
Nuclear signaling by ERBB4	REACTOME	R-HSA-1251985
Signaling by Leptin	REACTOME	R-HSA-2586552
AGE-RAGE signaling pathway in diabetic complications	KEGG	ko04933
AGE-RAGE signaling pathway in diabetic complications	KEGG	hsa04933
Th1 and Th2 cell differentiation	KEGG	ko04658
Th1 and Th2 cell differentiation	KEGG	hsa04658
Th17 cell differentiation	KEGG	ko04659
Th17 cell differentiation	KEGG	hsa04659

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association
PA134992438	CAMK1D	Gene	Pathway	associated
PA24684	AKT1	Gene	Pathway	associated
PA24685	AKT2	Gene	Pathway	associated
PA24686	AKT3	Gene	Pathway	associated
PA248	NFKB1	Gene	Pathway	associated
PA26048	CAMK1	Gene	Pathway	associated
PA26049	CAMK1G	Gene	Pathway	associated
PA27749	ELK1	Gene	Pathway	associated
PA28212	FOS	Gene	Pathway	associated
PA283	MAPK8	Gene	Pathway	associated
PA296	RELA	Gene	Pathway	associated
PA29988	JAK1	Gene	Pathway	associated
PA30006	JUN	Gene	Pathway	associated
PA30616	MAPK1	Gene	Pathway	associated
PA30622	MAPK3	Gene	Pathway	associated
PA31353	MYC	Gene	Pathway	associated
PA31600	NFKB2	Gene	Pathway	associated
PA337	STAT3	Gene	Pathway	associated
PA33759	PRKCA	Gene	Pathway	associated
PA33761	PRKCB	Gene	Pathway	associated
PA33766	PRKCG	Gene	Pathway	associated
PA36042	SP1	Gene	Pathway	associated
PA36183	STAT1	Gene	Pathway	associated
PA36184	STAT2	Gene	Pathway	associated
PA36185	STAT4	Gene	Pathway	associated
PA36186	STAT5B	Gene	Pathway	associated
PA90	CAMK2A	Gene	Pathway	associated
PA91	CAMK2B	Gene	Pathway	associated
PA92	CAMK2D	Gene	Pathway	associated
PA93	CAMK2G	Gene	Pathway	associated

References

Pubmed ID	Year	Title	Citations
37616578	2024	A novel EGFR variant EGFRx maintains glioblastoma stem cells through STAT5.	1
37802467	2024	Abnormal M1 polarization of placental macrophage induced by IL-15/STAT5 activation in VVC may lead to adverse pregnancy outcomes.	1
38347540	2024	IDH2/R140Q mutation confers cytokine-independent proliferation of TF-1 cells by activating constitutive STAT3/5 phosphorylation.	0
38360140	2024	STAT5 is essential for inducing the suppressive subset and attenuate cytotoxicity of Vδ2(+) T cells in acute myeloid leukemia.	0
38618957	2024	Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia.	0
38745318	2024	PAX6 promotes neuroendocrine phenotypes of prostate cancer via enhancing MET/STAT5A-mediated chromatin accessibility.	2
37616578	2024	A novel EGFR variant EGFRx maintains glioblastoma stem cells through STAT5.	1
37802467	2024	Abnormal M1 polarization of placental macrophage induced by IL-15/STAT5 activation in VVC may lead to adverse pregnancy outcomes.	1
38347540	2024	IDH2/R140Q mutation confers cytokine-independent proliferation of TF-1 cells by activating constitutive STAT3/5 phosphorylation.	0
38360140	2024	STAT5 is essential for inducing the suppressive subset and attenuate cytotoxicity of Vδ2(+) T cells in acute myeloid leukemia.	0
38618957	2024	Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia.	0
38745318	2024	PAX6 promotes neuroendocrine phenotypes of prostate cancer via enhancing MET/STAT5A-mediated chromatin accessibility.	2
36905318	2023	Stat5 inhibits NLRP3-mediated pyroptosis to enhance chemoresistance of breast cancer cells via promoting miR-182 transcription.	2
37106040	2023	Dynamic chromatin accessibility licenses STAT5- and STAT6-dependent innate-like function of T(H)9 cells to promote allergic inflammation.	1
37196931	2023	STAT5A modulates gastric cancer progression via upregulation of CD44.	4

Citation

Dessen P

STAT5A (signal transducer and activator of transcription 5A)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42431/stat5a-(signal-transducer-and-activator-of-transcription-5a)