STIM1 (stromal interaction molecule 1)

2003-02-01  

Identity

HGNC
STIM1
LOCATION
11p15.4
LOCUSID
6786
ALIAS
D11S4896E,GOK,IMD10,STRMK,TAM,TAM1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6786
MIM: 605921
HGNC: 11386
Ensembl: ENSG00000167323

Variants:

dbSNP: 6786
ClinVar: 6786
TCGA: ENSG00000167323
COSMIC: STIM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167323ENST00000300737Q13586
ENSG00000167323ENST00000524822E9PRE4
ENSG00000167323ENST00000525055E9PMB4
ENSG00000167323ENST00000525403E9PRZ7
ENSG00000167323ENST00000526596H0YDB2
ENSG00000167323ENST00000527651Q13586
ENSG00000167323ENST00000528656E9PR09
ENSG00000167323ENST00000530554E9PJ19
ENSG00000167323ENST00000532610E9PN27
ENSG00000167323ENST00000532919E9PIQ8
ENSG00000167323ENST00000532990E9PR07
ENSG00000167323ENST00000533977E9PNJ4
ENSG00000167323ENST00000616714G0XQ39

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Calcium signaling pathwayKEGGhsa04020
Platelet activationKEGGhsa04611
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersREACTOMER-HSA-983695
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Platelet calcium homeostasisREACTOMER-HSA-418360
Elevation of cytosolic Ca2+ levelsREACTOMER-HSA-139853
Muscle contractionREACTOMER-HSA-397014
Cardiac conductionREACTOMER-HSA-5576891
Ion homeostasisREACTOMER-HSA-5578775

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382244532024STIM1 translocation to the nucleus protects cells from DNA damage.0
383409772024STIM1 regulates pancreatic β-cell behaviour: A modelling study.0
385262082024Insights into the dynamics of the Ca2+ release-activated Ca2+ channel pore-forming complex Orai1.0
387535102024Essential role of N-terminal SAM regions in STIM1 multimerization and function.0
387711472024Role of STIM1 in stretch-induced signaling in human airway smooth muscle.0
389189432024Association of HLA class II gene polymorphisms and expression levels of ORAI1/STIM1 genes in HIV-1‒positive patients with HIV-related dermatoses in Latvia.0
382244532024STIM1 translocation to the nucleus protects cells from DNA damage.0
383409772024STIM1 regulates pancreatic β-cell behaviour: A modelling study.0
385262082024Insights into the dynamics of the Ca2+ release-activated Ca2+ channel pore-forming complex Orai1.0
387535102024Essential role of N-terminal SAM regions in STIM1 multimerization and function.0
387711472024Role of STIM1 in stretch-induced signaling in human airway smooth muscle.0
389189432024Association of HLA class II gene polymorphisms and expression levels of ORAI1/STIM1 genes in HIV-1‒positive patients with HIV-related dermatoses in Latvia.0
364046832023Knockdown of Stromal Interaction Molecule 1 (STIM1) Suppresses Acute Myeloblastic Leukemia-M5 Cell Line Survival Through Inhibition of Reactive Oxygen Species Activities.1
365244412023STIM1 and ORAI1 form a novel cold transduction mechanism in sensory and sympathetic neurons.4
366778742023The miRNA-185-5p/STIM1 Axis Regulates the Invasiveness of Nasopharyngeal Carcinoma Cell Lines by Modulating EGFR Activation-Stimulated Switch from E- to N-Cadherin.2

Citation

Dessen P

STIM1 (stromal interaction molecule 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42436/stim1-(stromal-interaction-molecule-1)