STIM1 (stromal interaction molecule 1)

2003-02-01  

Identity

HGNC
LOCATION
11p15.4
LOCUSID
ALIAS
D11S4896E,GOK,IMD10,STRMK,TAM,TAM1
FUSION GENES

Other Information

Locus ID:

NCBI: 6786
MIM: 605921
HGNC: 11386
Ensembl: ENSG00000167323

Variants:

dbSNP: 6786
ClinVar: 6786
TCGA: ENSG00000167323
COSMIC: STIM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167323ENST00000300737Q13586
ENSG00000167323ENST00000524822E9PRE4
ENSG00000167323ENST00000525055E9PMB4
ENSG00000167323ENST00000525403E9PRZ7
ENSG00000167323ENST00000526596H0YDB2
ENSG00000167323ENST00000527651Q13586
ENSG00000167323ENST00000528656E9PR09
ENSG00000167323ENST00000530554E9PJ19
ENSG00000167323ENST00000532610E9PN27
ENSG00000167323ENST00000532919E9PIQ8
ENSG00000167323ENST00000532990E9PR07
ENSG00000167323ENST00000533977E9PNJ4
ENSG00000167323ENST00000616714G0XQ39

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Calcium signaling pathwayKEGGhsa04020
Platelet activationKEGGhsa04611
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersREACTOMER-HSA-983695
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Platelet calcium homeostasisREACTOMER-HSA-418360
Elevation of cytosolic Ca2+ levelsREACTOMER-HSA-139853
Muscle contractionREACTOMER-HSA-397014
Cardiac conductionREACTOMER-HSA-5576891
Ion homeostasisREACTOMER-HSA-5578775

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
160052982005STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx.831
192490862009STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1.412
169664222006Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane.334
191827902009SOAR and the polybasic STIM1 domains gate and regulate Orai channels.297
175175962007Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion.276
169061492006STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels.263
229142932012STIM proteins: dynamic calcium signal transducers.243
191858472009Orai1 and STIM1 are critical for breast tumor cell migration and metastasis.234
167335272006Amplification of CRAC current by STIM1 and CRACM1 (Orai1).233
167665332006Orai1 and STIM reconstitute store-operated calcium channel function.230

Citation

Dessen P

STIM1 (stromal interaction molecule 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42436/stim1-(stromal-interaction-molecule-1)