STK17B (serine/threonine kinase 17b)

2003-11-01  

Identity

HGNC
LOCATION
2q32.3
LOCUSID
ALIAS
DRAK2
FUSION GENES

Other Information

Locus ID:

NCBI: 9262
MIM: 604727
HGNC: 11396
Ensembl: ENSG00000081320

Variants:

dbSNP: 9262
ClinVar: 9262
TCGA: ENSG00000081320
COSMIC: STK17B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000081320ENST00000263955O94768
ENSG00000081320ENST00000263955Q53QE7
ENSG00000081320ENST00000409228O94768
ENSG00000081320ENST00000409228Q53QE7
ENSG00000081320ENST00000420683C9JZJ1
ENSG00000081320ENST00000606789U3KQF8

Expression (GTEx)

0
10
20
30
40
50
60

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
383246362024DRAK2 suppresses autophagy by phosphorylating ULK1 at Ser(56) to diminish pancreatic β cell function upon overnutrition.0
383246362024DRAK2 suppresses autophagy by phosphorylating ULK1 at Ser(56) to diminish pancreatic β cell function upon overnutrition.0
346144092021DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing.28
346144092021DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing.28
330812452020DAP Kinase-Related Apoptosis-Inducing Protein Kinase 2 (DRAK2) Is a Key Regulator and Molecular Marker in Chronic Lymphocytic Leukemia.3
330812452020DAP Kinase-Related Apoptosis-Inducing Protein Kinase 2 (DRAK2) Is a Key Regulator and Molecular Marker in Chronic Lymphocytic Leukemia.3
294451892018STK17B promotes carcinogenesis and metastasis via AKT/GSK-3β/Snail signaling in hepatocellular carcinoma.26
294451892018STK17B promotes carcinogenesis and metastasis via AKT/GSK-3β/Snail signaling in hepatocellular carcinoma.26
233989432013The MYB oncogene can suppress apoptosis in acute myeloid leukemia cells by transcriptional repression of DRAK2 expression.14
240863682013An epistatic interaction between the PAX8 and STK17B genes in papillary thyroid cancer susceptibility.3
233989432013The MYB oncogene can suppress apoptosis in acute myeloid leukemia cells by transcriptional repression of DRAK2 expression.14
240863682013An epistatic interaction between the PAX8 and STK17B genes in papillary thyroid cancer susceptibility.3
231229562012DRAK2 participates in a negative feedback loop to control TGF-β/Smads signaling by binding to type I TGF-β receptor.18
231229562012DRAK2 participates in a negative feedback loop to control TGF-β/Smads signaling by binding to type I TGF-β receptor.18
211487962011Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation.9

Citation

Dessen P

STK17B (serine/threonine kinase 17b)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42438/stk17b-(serine-threonine-kinase-17b)