STRN3 (striatin 3)

2003-05-01  

Identity

HGNC
STRN3
LOCATION
14q12
LOCUSID
29966
ALIAS
PPP2R6B,S/G2NA,SG2NA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 29966
MIM: 614766
HGNC: 15720
Ensembl: ENSG00000196792

Variants:

dbSNP: 29966
ClinVar: 29966
TCGA: ENSG00000196792
COSMIC: STRN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196792ENST00000355683Q13033
ENSG00000196792ENST00000357479Q13033
ENSG00000196792ENST00000554991H0YJZ4
ENSG00000196792ENST00000555152G3V3G7
ENSG00000196792ENST00000555358G3V340
ENSG00000196792ENST00000556577H0YJT2

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384299012024STRN3 promotes tumour growth in hepatocellular carcinoma by inhibiting the hippo pathway.1
384299012024STRN3 promotes tumour growth in hepatocellular carcinoma by inhibiting the hippo pathway.1
366023062023Phosphorylation of Influenza A Virus Matrix Protein 1 at Threonine 108 Controls Its Multimerization State and Functional Association with the STRIPAK Complex.3
366023062023Phosphorylation of Influenza A Virus Matrix Protein 1 at Threonine 108 Controls Its Multimerization State and Functional Association with the STRIPAK Complex.3
352306052022The profile of expression of the scaffold protein SG2NA(s) differs between cancer types and its interactome in normal vis-a-vis breast tumor tissues suggests its wide roles in regulating multiple cellular pathways.2
352306052022The profile of expression of the scaffold protein SG2NA(s) differs between cancer types and its interactome in normal vis-a-vis breast tumor tissues suggests its wide roles in regulating multiple cellular pathways.2
325899422020Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer.42
325899422020Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer.42
305208182019Novel NTRK3 Fusions in Fibrosarcomas of Adults.19
305208182019Novel NTRK3 Fusions in Fibrosarcomas of Adults.19
255317792015STRIPAK components determine mode of cancer cell migration and metastasis.92
260221252015SG2NA enhances cancer cell survival by stabilizing DJ-1 and thus activating Akt.10
255317792015STRIPAK components determine mode of cancer cell migration and metastasis.92
260221252015SG2NA enhances cancer cell survival by stabilizing DJ-1 and thus activating Akt.10
245503882014Striatins contain a noncanonical coiled coil that binds protein phosphatase 2A A subunit to form a 2:2 heterotetrameric core of striatin-interacting phosphatase and kinase (STRIPAK) complex.24

Citation

Dessen P

STRN3 (striatin 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42446/strn3-(striatin-3)