SUFU (SUFU negative regulator of hedgehog signaling)

2003-02-01  

Identity

HGNC
SUFU
LOCATION
10q24.32
LOCUSID
51684
ALIAS
JBTS32,PRO1280,SUFUH,SUFUXL
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51684
MIM: 607035
HGNC: 16466
Ensembl: ENSG00000107882

Variants:

dbSNP: 51684
ClinVar: 51684
TCGA: ENSG00000107882
COSMIC: SUFU

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107882ENST00000369899Q9UMX1
ENSG00000107882ENST00000369902Q9UMX1
ENSG00000107882ENST00000423559Q9UMX1

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Hedgehog signaling pathwayKEGGko04340
Basal cell carcinomaKEGGko05217
Hedgehog signaling pathwayKEGGhsa04340
Pathways in cancerKEGGhsa05200
Basal cell carcinomaKEGGhsa05217
Hedgehog signalingKEGGhsa_M00678
Hedgehog signalingKEGGM00678
Signal TransductionREACTOMER-HSA-162582
Signaling by HedgehogREACTOMER-HSA-5358351
Hedgehog 'off' stateREACTOMER-HSA-5610787
GLI3 is processed to GLI3R by the proteasomeREACTOMER-HSA-5610785
Degradation of GLI2 by the proteasomeREACTOMER-HSA-5610783
Degradation of GLI1 by the proteasomeREACTOMER-HSA-5610780
Hedgehog 'on' stateREACTOMER-HSA-5632684

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365243562023WNT5A, β‑catenin and SUFU expression patterns, and the significance of microRNA deregulation in placentas with intrauterine growth restriction.1
365243562023WNT5A, β‑catenin and SUFU expression patterns, and the significance of microRNA deregulation in placentas with intrauterine growth restriction.1
358310232022ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1.6
358310232022ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1.6
330243172021Heterozygous truncating variants in SUFU cause congenital ocular motor apraxia.7
338930862021Differences in RNA and microRNA Expression Between PTCH1- and SUFU-mutated Medulloblastoma.1
342603782021Sufu negatively regulates both initiations of centrosome duplication and DNA replication.2
330243172021Heterozygous truncating variants in SUFU cause congenital ocular motor apraxia.7
338930862021Differences in RNA and microRNA Expression Between PTCH1- and SUFU-mutated Medulloblastoma.1
342603782021Sufu negatively regulates both initiations of centrosome duplication and DNA replication.2
330175702020SUFU mediates EMT and Wnt/β-catenin signaling pathway activation promoted by miRNA-324-5p in human gastric cancer.10
330175702020SUFU mediates EMT and Wnt/β-catenin signaling pathway activation promoted by miRNA-324-5p in human gastric cancer.10
305549982019Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma.27
311270252019LIFR-AS1 modulates Sufu to inhibit cell proliferation and migration by miR-197-3p in breast cancer.24
305549982019Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma.27

Citation

Dessen P

SUFU (SUFU negative regulator of hedgehog signaling)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42447/sufu-(sufu-negative-regulator-of-hedgehog-signaling)