EIF1 (eukaryotic translation initiation factor 1)

2003-06-01  

Identity

HGNC
EIF1
LOCATION
17q21.2
LOCUSID
10209
ALIAS
A121,EIF-1,EIF1A,ISO1,SUI1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10209
HGNC: 3249
Ensembl: ENSG00000173812

Variants:

dbSNP: 10209
ClinVar: 10209
TCGA: ENSG00000173812
COSMIC: EIF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173812ENST00000469257P41567
ENSG00000173812ENST00000469257Q6IAV3
ENSG00000173812ENST00000586699K7EQP2
ENSG00000173812ENST00000591776K7EM18

Expression (GTEx)

0
100
200
300
400
500
600
700
800
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013

References

Pubmed IDYearTitleCitations
209213842010Initiation context modulates autoregulation of eukaryotic translation initiation factor 1 (eIF1).57
232930292013Coordinated movements of eukaryotic translation initiation factors eIF1, eIF1A, and eIF5 trigger phosphate release from eIF2 in response to start codon recognition by the ribosomal preinitiation complex.38
228137442012The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2β.35
257384622015Translational tolerance of mitochondrial genes to metabolic energy stress involves TISU and eIF1-eIF4GI cooperation in start codon selection.27
252465242014Human eukaryotic initiation factor 2 (eIF2)-GTP-Met-tRNAi ternary complex and eIF3 stabilize the 43 S preinitiation complex.15
306042252019C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A.10
260184922015eIF1A augments Ago2-mediated Dicer-independent miRNA biogenesis and RNA interference.7
302115442018Human eIF5 and eIF1A Compete for Binding to eIF5B.4
263867242016Autoantibody response to Sui1 and its tissue-specific expression in hepatocellular carcinoma.1
299871882018Dynamic Interaction of Eukaryotic Initiation Factor 4G1 (eIF4G1) with eIF4E and eIF1 Underlies Scanning-Dependent and -Independent Translation.1

Citation

Dessen P

EIF1 (eukaryotic translation initiation factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42448/eif1-(eukaryotic-translation-initiation-factor-1)