SULT1A1 (sulfotransferase family 1A member 1)

2003-02-01 Affiliation

Identity

HGNC

SULT1A1

LOCATION

16p11.2

LOCUSID

6817

ALIAS

HAST1/HAST2,P-PST,P-PST

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6817
MIM: 171150
HGNC: 11453
Ensembl: ENSG00000196502

Variants:

dbSNP: 6817
ClinVar: 6817
TCGA: ENSG00000196502
COSMIC: SULT1A1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000196502	ENST00000314752	P50225
ENSG00000196502	ENST00000350842	P50225
ENSG00000196502	ENST00000395607	P50225
ENSG00000196502	ENST00000395609	P50225
ENSG00000196502	ENST00000562058	H3BMH9
ENSG00000196502	ENST00000563493	H3BT96
ENSG00000196502	ENST00000564818	H3BMH9
ENSG00000196502	ENST00000566189	H3BRY5
ENSG00000196502	ENST00000567512	H3BQX5
ENSG00000196502	ENST00000569554	P50225

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Metabolism	REACTOME	R-HSA-1430728
Biological oxidations	REACTOME	R-HSA-211859
Phase II conjugation	REACTOME	R-HSA-156580
Cytosolic sulfonation of small molecules	REACTOME	R-HSA-156584

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA164754789	conjugated estrogens	Chemical	ClinicalAnnotation	associated		PD	16985250
PA165947774	SULT1A1*2	Haplotype	VipGene	associated
PA166154995	rs750155	Variant	VipGene	associated			15970794
PA166155019	rs1801030	Variant	VipGene	associated			11207031, 10413297
PA166155051	rs3760091	Variant	VipGene	associated			15970794
PA166155089	rs9282861	Variant	VipGene	associated			10423517, 10959796, 11207031, 11535246, 14520706, 14973106, 15093672, 15377847, 15632378, 16141802, 18368507, 9345314, 10413297
PA166163690	desmethylnaproxen	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK
PA166179720	tapentadol	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK
PA443560	Breast Neoplasms	Disease	VipGene	associated			15093672, 15377847, 16141802, 14520706
PA444101	Esophageal Neoplasms	Disease	VipGene	associated			16272171
PA445208	Pain	Disease	ClinicalAnnotation	associated		PD	30908574
PA445425	Prostatic Neoplasms	Disease	VipGene	associated			14973106, 10959796
PA446108	Colorectal Neoplasms	Disease	VipGene	associated
PA446411	Endometrial Neoplasms	Disease	ClinicalAnnotation	associated		PD	16985250
PA448015	acetaminophen	Chemical	ClinicalAnnotation, Literature, MultilinkAnnotation, Pathway, VipGene	associated	PK	PD	23462933, 26049587, 30908574, 6957279
PA449509	estrogens	Chemical	VipGene	associated			11906176, 12034366, 9068609, 11062153
PA450521	minoxidil	Chemical	VipGene	associated			2390100

References

Pubmed ID	Year	Title	Citations
15632378	2005	CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment.	205
12867492	2003	Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties.	133
15952058	2005	Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients.	87
17244352	2007	Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer.	73
15987423	2005	Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients.	62
12419832	2002	A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer.	58
16006997	2005	A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer.	52
17947222	2008	Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism.	47
12471039	2003	Structure of a human carcinogen-converting enzyme, SULT1A1. Structural and kinetic implications of substrate inhibition.	44
18990750	2008	Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk.	44

Citation

Dessen P

SULT1A1 (sulfotransferase family 1A member 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42449/sult1a1