Identity
HGNC
LOCATION
17q11.2
LOCUSID
ALIAS
SPT6,SPT6H,emb-5
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6830
MIM: 601333
HGNC: 11470
Ensembl: ENSG00000109111
Variants:
dbSNP: 6830
ClinVar: 6830
TCGA: ENSG00000109111
COSMIC: SUPT6H
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000109111 | ENST00000314616 | Q7KZ85 |
| ENSG00000109111 | ENST00000347486 | Q7KZ85 |
| ENSG00000109111 | ENST00000577713 | J3QS64 |
| ENSG00000109111 | ENST00000584312 | K7EK85 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36852700 | 2023 | Hypermethylation-Mediated lncRNA MAGI2-AS3 Downregulation Facilitates Malignant Progression of Laryngeal Squamous Cell Carcinoma via Interacting With SPT6. | 2 |
| 37481442 | 2023 | Insights into Spt6: a histone chaperone that functions in transcription, DNA replication, and genome stability. | 3 |
| 36852700 | 2023 | Hypermethylation-Mediated lncRNA MAGI2-AS3 Downregulation Facilitates Malignant Progression of Laryngeal Squamous Cell Carcinoma via Interacting With SPT6. | 2 |
| 37481442 | 2023 | Insights into Spt6: a histone chaperone that functions in transcription, DNA replication, and genome stability. | 3 |
| 33305480 | 2021 | SPT6 recruits SND1 to co-activate human telomerase reverse transcriptase to promote colon cancer progression. | 8 |
| 33542242 | 2021 | SPT6 promotes epidermal differentiation and blockade of an intestinal-like phenotype through control of transcriptional elongation. | 8 |
| 34146481 | 2021 | Two distinct mechanisms of RNA polymerase II elongation stimulation in vivo. | 37 |
| 34233157 | 2021 | Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination. | 25 |
| 33305480 | 2021 | SPT6 recruits SND1 to co-activate human telomerase reverse transcriptase to promote colon cancer progression. | 8 |
| 33542242 | 2021 | SPT6 promotes epidermal differentiation and blockade of an intestinal-like phenotype through control of transcriptional elongation. | 8 |
| 34146481 | 2021 | Two distinct mechanisms of RNA polymerase II elongation stimulation in vivo. | 37 |
| 34233157 | 2021 | Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination. | 25 |
| 32522980 | 2020 | Spt6 is a maintenance factor for centromeric CENP-A. | 24 |
| 32948765 | 2020 | SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells. | 14 |
| 32522980 | 2020 | Spt6 is a maintenance factor for centromeric CENP-A. | 24 |
Citation
Dessen P
SUPT6H (SPT6 homolog, histone chaperone and transcription elongation factor)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/42454/supt6h-(spt6-homolog-histone-chaperone-and-transcription-elongation-factor)
