TANK (TRAF family member associated NFKB activator)

2003-06-01 Affiliation

Identity

HGNC

TANK

LOCATION

2q24.2

LOCUSID

10010

ALIAS

I-TRAF,ITRAF,TRAF2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10010
MIM: 603893
HGNC: 11562
Ensembl: ENSG00000136560

Variants:

dbSNP: 10010
ClinVar: 10010
TCGA: ENSG00000136560
COSMIC: TANK

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000136560	ENST00000259075	Q92844
ENSG00000136560	ENST00000392749	Q92844
ENSG00000136560	ENST00000402568	E7EW82
ENSG00000136560	ENST00000403609	Q92844
ENSG00000136560	ENST00000405852	E7EQA9
ENSG00000136560	ENST00000406287	E7EVA2
ENSG00000136560	ENST00000429217	E7ENY2
ENSG00000136560	ENST00000432002	E7EV32
ENSG00000136560	ENST00000432692	E7EM55
ENSG00000136560	ENST00000437623	H7C3L4
ENSG00000136560	ENST00000439442	H7BZ28
ENSG00000136560	ENST00000440506	E7EWR8
ENSG00000136560	ENST00000441987	E9PEK1
ENSG00000136560	ENST00000456358	E7EMT6
ENSG00000136560	ENST00000457887	E7ERM9

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
RIG-I-like receptor signaling pathway	KEGG	ko04622
RIG-I-like receptor signaling pathway	KEGG	hsa04622
NOD-like receptor signaling pathway	KEGG	ko04621
NOD-like receptor signaling pathway	KEGG	hsa04621
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Toll-Like Receptors Cascades	REACTOME	R-HSA-168898
Toll Like Receptor 3 (TLR3) Cascade	REACTOME	R-HSA-168164
MyD88-independent TLR3/TLR4 cascade	REACTOME	R-HSA-166166
TRIF-mediated TLR3/TLR4 signaling	REACTOME	R-HSA-937061
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	REACTOME	R-HSA-936964
Toll Like Receptor 4 (TLR4) Cascade	REACTOME	R-HSA-166016
Activated TLR4 signalling	REACTOME	R-HSA-166054
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	REACTOME	R-HSA-168928
TRAF6 mediated IRF7 activation	REACTOME	R-HSA-933541

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37215097	2023	TANK shapes an immunosuppressive microenvironment and predicts prognosis and therapeutic response in glioma.	0
37215097	2023	TANK shapes an immunosuppressive microenvironment and predicts prognosis and therapeutic response in glioma.	0
31486084	2020	CARD14/CARMA2sh and TANK differentially regulate poly(I:C)-induced inflammatory reaction in keratinocytes.	3
33316896	2020	UBAC1/KPC2 Regulates TLR3 Signaling in Human Keratinocytes through Functional Interaction with the CARD14/CARMA2sh-TANK Complex.	6
31486084	2020	CARD14/CARMA2sh and TANK differentially regulate poly(I:C)-induced inflammatory reaction in keratinocytes.	3
33316896	2020	UBAC1/KPC2 Regulates TLR3 Signaling in Human Keratinocytes through Functional Interaction with the CARD14/CARMA2sh-TANK Complex.	6
30721969	2019	The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study.	5
30721969	2019	The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study.	5
28155233	2017	Molecular basis for TANK recognition by TRAF1 revealed by the crystal structure of TRAF1/TANK complex.	9
28487378	2017	Encephalomyocarditis virus 3C protease attenuates type I interferon production through disrupting the TANK-TBK1-IKKε-IRF3 complex.	22
28566380	2017	Seneca Valley Virus Suppresses Host Type I Interferon Production by Targeting Adaptor Proteins MAVS, TRIF, and TANK for Cleavage.	72
28155233	2017	Molecular basis for TANK recognition by TRAF1 revealed by the crystal structure of TRAF1/TANK complex.	9
28487378	2017	Encephalomyocarditis virus 3C protease attenuates type I interferon production through disrupting the TANK-TBK1-IKKε-IRF3 complex.	22
28566380	2017	Seneca Valley Virus Suppresses Host Type I Interferon Production by Targeting Adaptor Proteins MAVS, TRIF, and TANK for Cleavage.	72
25861989	2015	TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase.	53

Citation

Dessen P

TANK (TRAF family member associated NFKB activator)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42468/tank-(traf-family-member-associated-nfkb-activator)