TAP1 (transporter 1, ATP binding cassette subfamily B member)

2003-02-01  

Identity

HGNC
TAP1
LOCATION
6p21.32
LOCUSID
6890
ALIAS
ABC17,ABCB2,APT1,D6S114E,PSF-1,PSF1,RING4,TAP1*0102N,TAP1N
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6890
MIM: 170260
HGNC: 43
Ensembl: ENSG00000168394

Variants:

dbSNP: 6890
ClinVar: 6890
TCGA: ENSG00000168394
COSMIC: TAP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168394ENST00000354258Q03518
ENSG00000168394ENST00000354258A0A0S2Z5A6
ENSG00000168394ENST00000643049A0A0S2Z4R8

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
ABC transportersKEGGko02010
Antigen processing and presentationKEGGko04612
Primary immunodeficiencyKEGGko05340
ABC transportersKEGGhsa02010
Antigen processing and presentationKEGGhsa04612
Primary immunodeficiencyKEGGhsa05340
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen Presentation: Folding, assembly and peptide loading of class I MHCREACTOMER-HSA-983170
Antigen processing-Cross presentationREACTOMER-HSA-1236975
ER-Phagosome pathwayREACTOMER-HSA-1236974

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
367597632023Pan-cancer analysis: predictive role of TAP1 in cancer prognosis and response to immunotherapy.4
367744902023TAP1, a potential immune-related prognosis biomarker with functional significance in uveal melanoma.1
367597632023Pan-cancer analysis: predictive role of TAP1 in cancer prognosis and response to immunotherapy.4
367744902023TAP1, a potential immune-related prognosis biomarker with functional significance in uveal melanoma.1
349734982022Spotlight on TAP and its vital role in antigen presentation and cross-presentation.21
354853662022Association study of TAP and HLA-I gene combination with chronic hepatitis C virus infection in a Han population in China.0
358061872022Antigen Peptide Transporter 1 (TAP1) Promotes Resistance to MEK Inhibitors in Pancreatic Cancers.2
349734982022Spotlight on TAP and its vital role in antigen presentation and cross-presentation.21
354853662022Association study of TAP and HLA-I gene combination with chronic hepatitis C virus infection in a Han population in China.0
358061872022Antigen Peptide Transporter 1 (TAP1) Promotes Resistance to MEK Inhibitors in Pancreatic Cancers.2
335075462021Association between the TAP1 gene polymorphisms and recurrent respiratory papillomatosis in patients from Western Mexico: A pilot study.3
337367392021Associations of genetic variants at TAP1 and TAP2 with pulmonary tuberculosis risk among the Chinese population.6
339250892021Broadly Antiviral Activities of TAP1 through Activating the TBK1-IRF3-Mediated Type I Interferon Production.11
340478122021Transporter associated with antigen processing 1 (TAP1) expression and prognostic analysis in breast, lung, liver, and ovarian cancer.22
340506052021Polymorphisms in transporter associated with antigen presenting are associated with cervical intraepithelial neoplasia and cervical cancer in a Chinese Han population.5

Citation

Dessen P

TAP1 (transporter 1, ATP binding cassette subfamily B member)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42469/tap1-(transporter-1-atp-binding-cassette-subfamily-b-member)