Identity
HGNC
LOCATION
12q14.2
LOCUSID
ALIAS
FTDALS4,IIAE8,NAK,T2K
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 29110
MIM: 604834
HGNC: 11584
Ensembl: ENSG00000183735
Variants:
dbSNP: 29110
ClinVar: 29110
TCGA: ENSG00000183735
COSMIC: TBK1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37733921 | 2024 | AZI2 mediates TBK1 activation at unresolved selective autophagy cargo receptor complexes with implications for CD8 T-cell infiltration in breast cancer. | 0 |
| 38007552 | 2024 | Activating STING/TBK1 suppresses tumor growth via degrading HPV16/18 E7 oncoproteins in cervical cancer. | 3 |
| 38038390 | 2024 | Cutting Edge: STING Induces ACLY Activation and Metabolic Adaptations in Human Macrophages through TBK1. | 2 |
| 38059900 | 2024 | NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis. | 0 |
| 38186000 | 2024 | STING upregulation mediates ferroptosis and inflammatory response in lupus nephritis by upregulating TBK1 and activating NF-κB signal pathway. | 0 |
| 38211588 | 2024 | Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma. | 0 |
| 38287189 | 2024 | Optineurin provides a mitophagy contact site for TBK1 activation. | 3 |
| 38351659 | 2024 | Phosphorylation of AGO2 by TBK1 Promotes the Formation of Oncogenic miRISC in NSCLC. | 2 |
| 38517332 | 2024 | A TBK1 variant causes autophagolysosomal and motoneuron pathology without neuroinflammation in mice. | 0 |
| 38563732 | 2024 | The Ca(2+)-dependent phosphatase calcineurin dephosphorylates TBK1 to suppress antiviral innate immunity. | 0 |
| 38673728 | 2024 | TANK Binding Kinase 1 Promotes BACH1 Degradation through Both Phosphorylation-Dependent and -Independent Mechanisms without Relying on Heme and FBXO22. | 0 |
| 38814780 | 2024 | TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery. | 1 |
| 38858497 | 2024 | Suppression of smooth muscle cell inflammation by myocardin-related transcription factors involves inactivation of TANK-binding kinase 1. | 1 |
| 38872230 | 2024 | Genetic and clinical landscape of Chinese frontotemporal dementia: dominance of TBK1 and OPTN mutations. | 0 |
| 38932169 | 2024 | cGAS-STING-TBK1 Signaling Promotes Valproic Acid-Responsive Human Cytomegalovirus Immediate-Early Transcription during Infection of Incompletely Differentiated Myeloid Cells. | 0 |
Citation
Dessen P
TBK1 (TANK binding kinase 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/42480/tbk1-(tank-binding-kinase-1)
