TCF7L1 (transcription factor 7 like 1)

2003-11-01  

Identity

HGNC
LOCATION
2p11.2
LOCUSID
ALIAS
TCF-3,TCF3
FUSION GENES

Other Information

Locus ID:

NCBI: 83439
MIM: 604652
HGNC: 11640
Ensembl: ENSG00000152284

Variants:

dbSNP: 83439
ClinVar: 83439
TCGA: ENSG00000152284
COSMIC: TCF7L1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152284ENST00000282111Q9HCS4
ENSG00000152284ENST00000442813C9JPE3

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Adherens junctionKEGGko04520
MelanogenesisKEGGko04916
Colorectal cancerKEGGko05210
Endometrial cancerKEGGko05213
Prostate cancerKEGGko05215
Thyroid cancerKEGGko05216
Basal cell carcinomaKEGGko05217
Acute myeloid leukemiaKEGGko05221
Wnt signaling pathwayKEGGhsa04310
Adherens junctionKEGGhsa04520
MelanogenesisKEGGhsa04916
Pathways in cancerKEGGhsa05200
Colorectal cancerKEGGhsa05210
Endometrial cancerKEGGhsa05213
Prostate cancerKEGGhsa05215
Thyroid cancerKEGGhsa05216
Basal cell carcinomaKEGGhsa05217
Acute myeloid leukemiaKEGGhsa05221
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGhsa05412
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Wnt signalingKEGGhsa_M00677
Wnt signalingKEGGM00677
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
Degradation of beta-catenin by the destruction complexREACTOMER-HSA-195253
Repression of WNT target genesREACTOMER-HSA-4641265
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Formation of the beta-catenin:TCF transactivating complexREACTOMER-HSA-201722
Binding of TCF/LEF:CTNNB1 to target gene promotersREACTOMER-HSA-4411364
Deactivation of the beta-catenin transactivating complexREACTOMER-HSA-3769402
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
Ca2+ pathwayREACTOMER-HSA-4086398
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

References

Pubmed IDYearTitleCitations
383703382024MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1.0
383703382024MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1.0
368334082023TCF7L1 Regulates LGR5 Expression in Colorectal Cancer Cells.2
368334082023TCF7L1 Regulates LGR5 Expression in Colorectal Cancer Cells.2
350785772022[T cell factor 3 (TCF3) is overexpressed in hepatocellular carcinoma and promotes their invasion and metastasis].0
350785772022[T cell factor 3 (TCF3) is overexpressed in hepatocellular carcinoma and promotes their invasion and metastasis].0
338248762021TCF7L1 Genetic Variants Are Associated with the Susceptibility to Cervical Cancer in a Chinese Population.0
338248762021TCF7L1 Genetic Variants Are Associated with the Susceptibility to Cervical Cancer in a Chinese Population.0
324033232020Diverse LEF/TCF Expression in Human Colorectal Cancer Correlates with Altered Wnt-Regulated Transcriptome in a Meta-Analysis of Patient Biopsies.9
324033232020Diverse LEF/TCF Expression in Human Colorectal Cancer Correlates with Altered Wnt-Regulated Transcriptome in a Meta-Analysis of Patient Biopsies.9
308115262019TCF7L1 indicates prognosis and promotes proliferation through activation of Keap1/NRF2 in gastric cancer.13
313227822019Tcf7l1 Acts as a Suppressor for the Self-Renewal of Liver Cancer Stem Cells and Is Regulated by IGF/MEK/ERK Signaling Independent of β-Catenin.9
313818752019Wnt suppressor and stem cell regulator TCF7L1 is a sensitive immunohistochemical marker to differentiate testicular seminoma from non-seminomatous germ cell tumor.4
308115262019TCF7L1 indicates prognosis and promotes proliferation through activation of Keap1/NRF2 in gastric cancer.13
313227822019Tcf7l1 Acts as a Suppressor for the Self-Renewal of Liver Cancer Stem Cells and Is Regulated by IGF/MEK/ERK Signaling Independent of β-Catenin.9

Citation

Dessen P

TCF7L1 (transcription factor 7 like 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42495/tcf7l1-(transcription-factor-7-like-1)