TDG (thymine DNA glycosylase)

2003-02-01  

Identity

HGNC
TDG
LOCATION
12q23.3
LOCUSID
6996
ALIAS
hTDG
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6996
MIM: 601423
HGNC: 11700
Ensembl: ENSG00000139372

Variants:

dbSNP: 6996
ClinVar: 6996
TCGA: ENSG00000139372
COSMIC: TDG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139372ENST00000266775G8JL98
ENSG00000139372ENST00000392872Q13569
ENSG00000139372ENST00000436021F5H539
ENSG00000139372ENST00000537100F5H0I7
ENSG00000139372ENST00000540956H0YH18
ENSG00000139372ENST00000544861B4E127

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Base excision repairKEGGko03410
Base excision repairKEGGhsa03410
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
Gene ExpressionREACTOMER-HSA-74160
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
TET1,2,3 and TDG demethylate DNAREACTOMER-HSA-5221030
DNA RepairREACTOMER-HSA-73894
Base Excision RepairREACTOMER-HSA-73884
Base-Excision Repair, AP Site FormationREACTOMER-HSA-73929
DepyrimidinationREACTOMER-HSA-73928
Recognition and association of DNA glycosylase with site containing an affected pyrimidineREACTOMER-HSA-110328
Cleavage of the damaged pyrimidineREACTOMER-HSA-110329
Resolution of Abasic Sites (AP sites)REACTOMER-HSA-73933
Displacement of DNA glycosylase by APEX1REACTOMER-HSA-110357

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
372240782023Comprehensive analysis of the prognostic value and biological function of TDG in hepatocellular carcinoma.1
372240782023Comprehensive analysis of the prognostic value and biological function of TDG in hepatocellular carcinoma.1
354147932022TDG suppresses the migration and invasion of human colon cancer cells via the DNMT3A/TIMP2 axis.6
354147932022TDG suppresses the migration and invasion of human colon cancer cells via the DNMT3A/TIMP2 axis.6
337336522021Reversible chromatin condensation by the DNA repair and demethylation factor thymine DNA glycosylase.9
346816902021Direct and Base Excision Repair-Mediated Regulation of a GC-Rich cis-Element in Response to 5-Formylcytosine and 5-Carboxycytosine.1
337336522021Reversible chromatin condensation by the DNA repair and demethylation factor thymine DNA glycosylase.9
346816902021Direct and Base Excision Repair-Mediated Regulation of a GC-Rich cis-Element in Response to 5-Formylcytosine and 5-Carboxycytosine.1
306749892019Thymine DNA glycosylase as a novel target for melanoma.25
307793282019Effect of the thymine-DNA glycosylase rs4135050 variant on Saudi smoker population.5
312821102019lncRNA H19 contributes to oxidative damage repair in the early age-related cataract by regulating miR-29a/TDG axis.24
306749892019Thymine DNA glycosylase as a novel target for melanoma.25
307793282019Effect of the thymine-DNA glycosylase rs4135050 variant on Saudi smoker population.5
312821102019lncRNA H19 contributes to oxidative damage repair in the early age-related cataract by regulating miR-29a/TDG axis.24
292532322018Dynamics of the excised base release in thymine DNA glycosylase during DNA repair process.12

Citation

Dessen P

TDG (thymine DNA glycosylase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42506/tdg-(thymine-dna-glycosylase)