TGFB1I1 (transforming growth factor beta 1 induced transcript 1)

2003-02-01 Affiliation

Identity

HGNC

TGFB1I1

LOCATION

16p11.2

LOCUSID

7041

ALIAS

ARA55,HIC-5,HIC5,TSC-5

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7041
MIM: 602353
HGNC: 11767
Ensembl: ENSG00000140682

Variants:

dbSNP: 7041
ClinVar: 7041
TCGA: ENSG00000140682
COSMIC: TGFB1I1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000140682	ENST00000361773	O43294
ENSG00000140682	ENST00000361773	A0A024QZE7
ENSG00000140682	ENST00000394858	O43294
ENSG00000140682	ENST00000394858	A0A024QZE7
ENSG00000140682	ENST00000394863	O43294
ENSG00000140682	ENST00000562566	H3BS04
ENSG00000140682	ENST00000563712	I3L209
ENSG00000140682	ENST00000564804	H3BN49
ENSG00000140682	ENST00000565360	H3BQC4
ENSG00000140682	ENST00000565454	H3BSN4
ENSG00000140682	ENST00000567066	H3BRP2
ENSG00000140682	ENST00000567607	O43294
ENSG00000140682	ENST00000567607	A0A024QZE7

Expression (GTEx)

100

200

300

400

500

600

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
21148292	2011	Distinct roles for paxillin and Hic-5 in regulating breast cancer cell morphology, invasion, and metastasis.	86
15561701	2005	Novel function of androgen receptor-associated protein 55/Hic-5 as a negative regulator of Smad3 signaling.	34
19389829	2009	The progesterone receptor coactivator Hic-5 is involved in the pathophysiology of endometriosis.	32
18401422	2008	Hic-5 promotes the hypertrophic scar myofibroblast phenotype by regulating the TGF-beta1 autocrine loop.	31
18762808	2008	Smad7 is inactivated through a direct physical interaction with the LIM protein Hic-5/ARA55.	29
12631731	2003	Hic-5 communicates between focal adhesions and the nucleus through oxidant-sensitive nuclear export signal.	25
21984848	2011	Transforming growth factor-β1-induced transcript 1 protein, a novel marker for smooth muscle contractile phenotype, is regulated by serum response factor/myocardin protein.	24
24831009	2014	Negative regulation of NADPH oxidase 4 by hydrogen peroxide-inducible clone 5 (Hic-5) protein.	21
27893716	2017	Hic-5 remodeling of the stromal matrix promotes breast tumor progression.	21
16849583	2006	Hic-5/ARA55, a LIM domain-containing nuclear receptor coactivator expressed in prostate stromal cells.	19

Citation

Dessen P

TGFB1I1 (transforming growth factor beta 1 induced transcript 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42535/tgfb1i1-(transforming-growth-factor-beta-1-induced-transcript-1)