THBS4 (thrombospondin 4)

2003-08-01  

Identity

HGNC
THBS4
LOCATION
5q14.1
LOCUSID
7060
ALIAS
TSP-4,TSP4

Other Information

Locus ID:

NCBI: 7060
MIM: 600715
HGNC: 11788
Ensembl: ENSG00000113296

Variants:

dbSNP: 7060
ClinVar: 7060
TCGA: ENSG00000113296
COSMIC: THBS4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113296ENST00000350881P35443
ENSG00000113296ENST00000511733E7ES19

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
ECM-receptor interactionKEGGko04512
Focal adhesionKEGGhsa04510
ECM-receptor interactionKEGGhsa04512
MalariaKEGGko05144
MalariaKEGGhsa05144
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Signal TransductionREACTOMER-HSA-162582
Signaling by PDGFREACTOMER-HSA-186797

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365665682023Stimulation with THBS4 activates pathways that regulate proliferation, migration and inflammation in primary human keratinocytes.3
365665682023Stimulation with THBS4 activates pathways that regulate proliferation, migration and inflammation in primary human keratinocytes.3
339108542021Pathological Significance and Prognostic Roles of Thrombospondin-3, 4 and 5 in Bladder Cancer.3
339713152021Spatiotemporal distribution of thrombospondin-4 and -5 in cartilage during endochondral bone formation and repair.8
343903282021THBS4/integrin α2 axis mediates BM-MSCs to promote angiogenesis in gastric cancer associated with chronic Helicobacter pylori infection.6
339108542021Pathological Significance and Prognostic Roles of Thrombospondin-3, 4 and 5 in Bladder Cancer.3
339713152021Spatiotemporal distribution of thrombospondin-4 and -5 in cartilage during endochondral bone formation and repair.8
343903282021THBS4/integrin α2 axis mediates BM-MSCs to promote angiogenesis in gastric cancer associated with chronic Helicobacter pylori infection.6
312278752020Thrombospondin-4 increases with the severity of peripheral arterial disease and is associated with diabetes.8
324218682020THBS4 silencing regulates the cancer stem cell-like properties in prostate cancer via blocking the PI3K/Akt pathway.16
325677402020THBS4 promotes HCC progression by regulating ITGB1 via FAK/PI3K/AKT pathway.38
312278752020Thrombospondin-4 increases with the severity of peripheral arterial disease and is associated with diabetes.8
324218682020THBS4 silencing regulates the cancer stem cell-like properties in prostate cancer via blocking the PI3K/Akt pathway.16
325677402020THBS4 promotes HCC progression by regulating ITGB1 via FAK/PI3K/AKT pathway.38
291381192019Thrombospondin-4 in tissue remodeling.46

Citation

Dessen P

THBS4 (thrombospondin 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42551/thbs4-(thrombospondin-4)