THBS4 (thrombospondin 4)

2003-08-01  

Identity

HGNC
LOCATION
5q14.1
LOCUSID
ALIAS
TSP-4,TSP4

Other Information

Locus ID:

NCBI: 7060
MIM: 600715
HGNC: 11788
Ensembl: ENSG00000113296

Variants:

dbSNP: 7060
ClinVar: 7060
TCGA: ENSG00000113296
COSMIC: THBS4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113296ENST00000350881P35443
ENSG00000113296ENST00000511733E7ES19

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
ECM-receptor interactionKEGGko04512
Focal adhesionKEGGhsa04510
ECM-receptor interactionKEGGhsa04512
MalariaKEGGko05144
MalariaKEGGhsa05144
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Signal TransductionREACTOMER-HSA-162582
Signaling by PDGFREACTOMER-HSA-186797

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
158975512005Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73.57
74902841995Thrombospondin-4, an extracellular matrix protein expressed in the developing and adult nervous system promotes neurite outgrowth.52
227454972012Thrombospondin-4 contributes to spinal sensitization and neuropathic pain states.46
206738682010A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).36
151217692004Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes.35
171829692007Increased cortical expression of two synaptogenic thrombospondins in human brain evolution.35
217015372011THBS4, a novel stromal molecule of diffuse-type gastric adenocarcinomas, identified by transcriptome-wide expression profiling.34
206286242010Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".29
249419432014Thrombospondin-4 controls matrix assembly during development and repair of myotendinous junctions.29

Citation

Dessen P

THBS4 (thrombospondin 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42551/thbs4-(thrombospondin-4)