Identity
HGNC
LOCATION
17q21.1
LOCUSID
ALIAS
AR7,CHNG6,EAR7,ERB-T-1,ERBA,ERBA1,NR1A1,THRA1,THRA2,TRalpha,c-ERBA-1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7067
MIM: 190120
HGNC: 11796
Ensembl: ENSG00000126351
Variants:
dbSNP: 7067
ClinVar: 7067
TCGA: ENSG00000126351
COSMIC: THRA
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA131285571 | aspirin-induced asthma | Disease | ClinicalAnnotation | associated | PD | ||
| PA443450 | Asthma | Disease | ClinicalAnnotation | associated | PD | ||
| PA447199 | Bipolar Disorder | Disease | ClinicalAnnotation | associated | PD | 20348464 | |
| PA448497 | aspirin | Chemical | ClinicalAnnotation | associated | PD | ||
| PA450243 | lithium | Chemical | ClinicalAnnotation | associated | PD | 20348464 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38654093 | 2024 | Spatiotemporal expression of thyroid hormone transporter MCT8 and THRA mRNA in human cerebral organoids recapitulating first trimester cortex development. | 2 |
| 38654093 | 2024 | Spatiotemporal expression of thyroid hormone transporter MCT8 and THRA mRNA in human cerebral organoids recapitulating first trimester cortex development. | 2 |
| 37634007 | 2023 | Thyroid hormone receptor α1: a novel regulator of thyroid cancer cell differentiation. | 3 |
| 37634007 | 2023 | Thyroid hormone receptor α1: a novel regulator of thyroid cancer cell differentiation. | 3 |
| 36217307 | 2022 | Regulation of the THRA gene, encoding the thyroid hormone nuclear receptor TRα1, in intestinal lesions. | 1 |
| 36217307 | 2022 | Regulation of the THRA gene, encoding the thyroid hormone nuclear receptor TRα1, in intestinal lesions. | 1 |
| 33509032 | 2021 | Germ Line Mutations in the Thyroid Hormone Receptor Alpha Gene Predispose to Cutaneous Tags and Melanocytic Nevi. | 8 |
| 33558878 | 2021 | Life Without Thyroid Hormone Receptor. | 19 |
| 33846395 | 2021 | Thyroid hormone receptor α1 acts as a new squamous cell lung cancer diagnostic marker and poor prognosis predictor. | 5 |
| 34069457 | 2021 | A New Mechanism in THRA Resistance: The First Disease-Associated Variant Leading to an Increased Inhibitory Function of THRA2. | 7 |
| 34930399 | 2021 | Low thyroid hormone receptor alpha-2 (THRα-2) tumor expression is associated with unfavorable tumor characteristics and high breast cancer mortality. | 6 |
| 33509032 | 2021 | Germ Line Mutations in the Thyroid Hormone Receptor Alpha Gene Predispose to Cutaneous Tags and Melanocytic Nevi. | 8 |
| 33558878 | 2021 | Life Without Thyroid Hormone Receptor. | 19 |
| 33846395 | 2021 | Thyroid hormone receptor α1 acts as a new squamous cell lung cancer diagnostic marker and poor prognosis predictor. | 5 |
| 34069457 | 2021 | A New Mechanism in THRA Resistance: The First Disease-Associated Variant Leading to an Increased Inhibitory Function of THRA2. | 7 |
Citation
Dessen P
THRA (thyroid hormone receptor alpha)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/42553/thra-(thyroid-hormone-receptor-alpha)
