THRA (thyroid hormone receptor alpha)

2003-02-01  

Identity

HGNC
THRA
LOCATION
17q21.1
LOCUSID
7067
ALIAS
AR7,CHNG6,EAR7,ERB-T-1,ERBA,ERBA1,NR1A1,THRA1,THRA2,TRalpha,c-ERBA-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7067
MIM: 190120
HGNC: 11796
Ensembl: ENSG00000126351

Variants:

dbSNP: 7067
ClinVar: 7067
TCGA: ENSG00000126351
COSMIC: THRA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126351ENST00000264637P10827
ENSG00000126351ENST00000394121P10827
ENSG00000126351ENST00000450525P10827
ENSG00000126351ENST00000450525Q6FH41
ENSG00000126351ENST00000546243P10827
ENSG00000126351ENST00000546243Q6FH41
ENSG00000126351ENST00000577288J3QR26
ENSG00000126351ENST00000577486J3QRW5
ENSG00000126351ENST00000578218J3QRA9
ENSG00000126351ENST00000584985P10827
ENSG00000126351ENST00000585047J3KTF3

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Thyroid hormone signaling pathwayKEGGhsa04919
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Nuclear Receptor transcription pathwayREACTOMER-HSA-383280

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA131285571aspirin-induced asthmaDiseaseClinicalAnnotationassociatedPD
PA443450AsthmaDiseaseClinicalAnnotationassociatedPD
PA447199Bipolar DisorderDiseaseClinicalAnnotationassociatedPD20348464
PA448497aspirinChemicalClinicalAnnotationassociatedPD
PA450243lithiumChemicalClinicalAnnotationassociatedPD20348464

References

Pubmed IDYearTitleCitations
386540932024Spatiotemporal expression of thyroid hormone transporter MCT8 and THRA mRNA in human cerebral organoids recapitulating first trimester cortex development.2
386540932024Spatiotemporal expression of thyroid hormone transporter MCT8 and THRA mRNA in human cerebral organoids recapitulating first trimester cortex development.2
376340072023Thyroid hormone receptor α1: a novel regulator of thyroid cancer cell differentiation.3
376340072023Thyroid hormone receptor α1: a novel regulator of thyroid cancer cell differentiation.3
362173072022Regulation of the THRA gene, encoding the thyroid hormone nuclear receptor TRα1, in intestinal lesions.1
362173072022Regulation of the THRA gene, encoding the thyroid hormone nuclear receptor TRα1, in intestinal lesions.1
335090322021Germ Line Mutations in the Thyroid Hormone Receptor Alpha Gene Predispose to Cutaneous Tags and Melanocytic Nevi.8
335588782021Life Without Thyroid Hormone Receptor.19
338463952021Thyroid hormone receptor α1 acts as a new squamous cell lung cancer diagnostic marker and poor prognosis predictor.5
340694572021A New Mechanism in THRA Resistance: The First Disease-Associated Variant Leading to an Increased Inhibitory Function of THRA2.7
349303992021Low thyroid hormone receptor alpha-2 (THRα-2) tumor expression is associated with unfavorable tumor characteristics and high breast cancer mortality.6
335090322021Germ Line Mutations in the Thyroid Hormone Receptor Alpha Gene Predispose to Cutaneous Tags and Melanocytic Nevi.8
335588782021Life Without Thyroid Hormone Receptor.19
338463952021Thyroid hormone receptor α1 acts as a new squamous cell lung cancer diagnostic marker and poor prognosis predictor.5
340694572021A New Mechanism in THRA Resistance: The First Disease-Associated Variant Leading to an Increased Inhibitory Function of THRA2.7

Citation

Dessen P

THRA (thyroid hormone receptor alpha)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42553/thra-(thyroid-hormone-receptor-alpha)