Identity
HGNC
LOCATION
9p13.3
LOCUSID
ALIAS
ILWEQ,TLN,talin-1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7094
MIM: 186745
HGNC: 11845
Ensembl: ENSG00000137076
Variants:
dbSNP: 7094
ClinVar: 7094
TCGA: ENSG00000137076
COSMIC: TLN1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000137076 | ENST00000314888 | Q9Y490 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37144848 | 2024 | TLN1 synergizes with ITGA5 to ameliorate cardiac microvascular endothelial cell dysfunction. | 2 |
| 38254102 | 2024 | HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling. | 0 |
| 37144848 | 2024 | TLN1 synergizes with ITGA5 to ameliorate cardiac microvascular endothelial cell dysfunction. | 2 |
| 38254102 | 2024 | HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling. | 0 |
| 36717550 | 2023 | The interaction of β-arrestin1 with talin1 driven by endothelin A receptor as a feature of α5β1 integrin activation in high-grade serous ovarian cancer. | 4 |
| 36880935 | 2023 | TLN1 contains a cancer-associated cassette exon that alters talin-1 mechanosensitivity. | 1 |
| 37395213 | 2023 | Talin1 regulates glucose metabolism and endometrial receptivity via GLUT-4 in patients with polycystic ovary syndrome and insulin resistance. | 1 |
| 37460470 | 2023 | BCKDK regulates breast cancer cell adhesion and tumor metastasis by inhibiting TRIM21 ubiquitinate talin1. | 3 |
| 36717550 | 2023 | The interaction of β-arrestin1 with talin1 driven by endothelin A receptor as a feature of α5β1 integrin activation in high-grade serous ovarian cancer. | 4 |
| 36880935 | 2023 | TLN1 contains a cancer-associated cassette exon that alters talin-1 mechanosensitivity. | 1 |
| 37395213 | 2023 | Talin1 regulates glucose metabolism and endometrial receptivity via GLUT-4 in patients with polycystic ovary syndrome and insulin resistance. | 1 |
| 37460470 | 2023 | BCKDK regulates breast cancer cell adhesion and tumor metastasis by inhibiting TRIM21 ubiquitinate talin1. | 3 |
| 35156729 | 2022 | Downregulation of Talin-1 is associated with the increased expression of miR-182-5p and miR-9-5p in coronary artery disease. | 4 |
| 35245171 | 2022 | The C-terminal actin-binding domain of talin forms an asymmetric catch bond with F-actin. | 32 |
| 35285795 | 2022 | Binding blockade between TLN1 and integrin β1 represses triple-negative breast cancer. | 9 |
Citation
Dessen P
TLN1 (talin 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/42578
