TLR1 (toll like receptor 1)

2003-10-01 Affiliation

Identity

HGNC

TLR1

LOCATION

4p14

LOCUSID

7096

ALIAS

CD281,TIL,TIL.

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7096
MIM: 601194
HGNC: 11847
Ensembl: ENSG00000174125

Variants:

dbSNP: 7096
ClinVar: 7096
TCGA: ENSG00000174125
COSMIC: TLR1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000174125	ENST00000308979	Q15399
ENSG00000174125	ENST00000502213	Q15399
ENSG00000174125	ENST00000505940	D6RAP2
ENSG00000174125	ENST00000506146	D6RCE8
ENSG00000174125	ENST00000508364	D6RF68
ENSG00000174125	ENST00000515861	D6RA99

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Toll-like receptor signaling pathway	KEGG	ko04620
Toll-like receptor signaling pathway	KEGG	hsa04620
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Disease	REACTOME	R-HSA-1643685
Diseases of Immune System	REACTOME	R-HSA-5260271
Diseases associated with the TLR signaling cascade	REACTOME	R-HSA-5602358
IRAK4 deficiency (TLR2/4)	REACTOME	R-HSA-5603041
MyD88 deficiency (TLR2/4)	REACTOME	R-HSA-5602498
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing-Cross presentation	REACTOME	R-HSA-1236975
ER-Phagosome pathway	REACTOME	R-HSA-1236974
Innate Immune System	REACTOME	R-HSA-168249
Toll-Like Receptors Cascades	REACTOME	R-HSA-168898
Toll Like Receptor 4 (TLR4) Cascade	REACTOME	R-HSA-166016
Activated TLR4 signalling	REACTOME	R-HSA-166054
MyD88:Mal cascade initiated on plasma membrane	REACTOME	R-HSA-166058
Toll Like Receptor 2 (TLR2) Cascade	REACTOME	R-HSA-181438
Toll Like Receptor TLR1:TLR2 Cascade	REACTOME	R-HSA-168179
Toll Like Receptor TLR6:TLR2 Cascade	REACTOME	R-HSA-168188
Defensins	REACTOME	R-HSA-1461973
Beta defensins	REACTOME	R-HSA-1461957
Regulation of TLR by endogenous ligand	REACTOME	R-HSA-5686938
Antimicrobial peptides	REACTOME	R-HSA-6803157

References

Pubmed ID	Year	Title	Citations
17889651	2007	Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide.	406
20100933	2010	Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response.	163
16880211	2006	Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting.	150
14966134	2004	Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1.	132
12091878	2002	Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice.	129
19503839	2009	Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses.	111
18056480	2008	Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling.	105
18006661	2007	Human -defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2.	103
17202359	2007	Age-associated defect in human TLR-1/2 function.	102
17703412	2007	Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.	100

Citation

Dessen P

TLR1 (toll like receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/42580/tlr1-(toll-like-receptor-1)