TSPAN7 (tetraspanin 7)

2003-11-01  

Identity

HGNC
TSPAN7
LOCATION
Xp11.4
LOCUSID
7102
ALIAS
A15,CCG-B7,CD231,DXS1692E,MRX58,MXS1,TALLA-1,TM4SF2,TM4SF2b
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7102
MIM: 300096
HGNC: 11854
Ensembl: ENSG00000156298

Variants:

dbSNP: 7102
ClinVar: 7102
TCGA: ENSG00000156298
COSMIC: TSPAN7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156298ENST00000286824B4DDG0
ENSG00000156298ENST00000378482P41732
ENSG00000156298ENST00000471410F8WF53
ENSG00000156298ENST00000475216F8WC96
ENSG00000156298ENST00000480976F8WF47

Expression (GTEx)

0
100
200
300
400
500
600
700
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Glutamate Binding, Activation of AMPA Receptors and Synaptic PlasticityREACTOMER-HSA-399721
Trafficking of AMPA receptorsREACTOMER-HSA-399719
Trafficking of GluR2-containing AMPA receptorsREACTOMER-HSA-416993
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
362642702022Loss of tetraspanin-7 expression reduces pancreatic β-cell exocytosis Ca(2+) sensitivity but has limited effect on systemic metabolism.2
362642702022Loss of tetraspanin-7 expression reduces pancreatic β-cell exocytosis Ca(2+) sensitivity but has limited effect on systemic metabolism.2
321811592020Dendritic Cell Maturation Regulates TSPAN7 Function in HIV-1 Transfer to CD4(+) T Lymphocytes.6
323140122020Autoimmunity to tetraspanin-7 in type 1 diabetes.10
324681302020Tetraspanin 7 and its closest paralog tetraspanin 6: membrane organizers with key functions in brain development, viral infection, innate immunity, diabetes and cancer.15
321811592020Dendritic Cell Maturation Regulates TSPAN7 Function in HIV-1 Transfer to CD4(+) T Lymphocytes.6
323140122020Autoimmunity to tetraspanin-7 in type 1 diabetes.10
324681302020Tetraspanin 7 and its closest paralog tetraspanin 6: membrane organizers with key functions in brain development, viral infection, innate immunity, diabetes and cancer.15
282233372017Functional expression of dopamine D2 receptor is regulated by tetraspanin 7-mediated postendocytic trafficking.16
286200312017TSPAN7, effector of actin nucleation required for dendritic cell-mediated transfer of HIV-1 to T cells.11
282233372017Functional expression of dopamine D2 receptor is regulated by tetraspanin 7-mediated postendocytic trafficking.16
286200312017TSPAN7, effector of actin nucleation required for dendritic cell-mediated transfer of HIV-1 to T cells.11
256372182015Tetraspanin 7 (TSPAN7) expression is upregulated in multiple myeloma patients and inhibits myeloma tumour development in vivo.23
256372182015Tetraspanin 7 (TSPAN7) expression is upregulated in multiple myeloma patients and inhibits myeloma tumour development in vivo.23
222131522012CD31, EDNRB and TSPAN7 are promising prognostic markers in clear-cell renal cell carcinoma revealed by genome-wide expression analyses of primary tumors and metastases.53

Citation

Dessen P

TSPAN7 (tetraspanin 7)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42584/tspan7-(tetraspanin-7)