TNFRSF10A (TNF receptor superfamily member 10a)

2003-06-01  

Identity

HGNC
LOCATION
8p21.3
LOCUSID
ALIAS
APO2,CD261,DR4,TRAILR-1,TRAILR1
FUSION GENES

Other Information

Locus ID:

NCBI: 8797
MIM: 603611
HGNC: 11904
Ensembl: ENSG00000104689

Variants:

dbSNP: 8797
ClinVar: 8797
TCGA: ENSG00000104689
COSMIC: TNFRSF10A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104689ENST00000221132O00220
ENSG00000104689ENST00000524158E5RFH1
ENSG00000104689ENST00000613472F8U8C0

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
ApoptosisKEGGko04210
Natural killer cell mediated cytotoxicityKEGGko04650
Cytokine-cytokine receptor interactionKEGGhsa04060
ApoptosisKEGGhsa04210
Natural killer cell mediated cytotoxicityKEGGhsa04650
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Signal TransductionREACTOMER-HSA-162582
Death Receptor SignallingREACTOMER-HSA-73887
TRAIL signalingREACTOMER-HSA-75158
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Caspase activation via extrinsic apoptotic signalling pathwayREACTOMER-HSA-5357769
Ligand-dependent caspase activationREACTOMER-HSA-140534
Dimerization of procaspase-8REACTOMER-HSA-69416
Regulation by c-FLIPREACTOMER-HSA-3371378
Regulated NecrosisREACTOMER-HSA-5218859
RIPK1-mediated regulated necrosisREACTOMER-HSA-5213460
Regulation of necroptotic cell deathREACTOMER-HSA-5675482
CASP8 activity is inhibitedREACTOMER-HSA-5218900
TP53 Regulates Transcription of Cell Death GenesREACTOMER-HSA-5633008
TP53 Regulates Transcription of Death Receptors and LigandsREACTOMER-HSA-6803211

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164713366Tumor necrosis factor alpha (TNF-alpha) inhibitorsChemicalClinicalAnnotationassociatedPD22480748
PA443430ArthritisDiseaseClinicalAnnotationassociatedPD22480748

References

Pubmed IDYearTitleCitations
190748312008TRAIL resistance of breast cancer cells is associated with constitutive endocytosis of death receptors 4 and 5.89
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
219530562012miR-25 targets TNF-related apoptosis inducing ligand (TRAIL) death receptor-4 and promotes apoptosis resistance in cholangiocarcinoma.82
179838092007Hepatitis C virus triggers apoptosis of a newly developed hepatoma cell line through antiviral defense system.55
234989572013Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses.46
155389682004Following a TRAIL: update on a ligand and its five receptors.43
213678582011Toll-like receptor 3 (TLR3) induces apoptosis via death receptors and mitochondria by up-regulating the transactivating p63 isoform alpha (TAP63alpha).42
178819042007Chemotherapy-resistant side-population of colon cancer cells has a higher sensitivity to TRAIL than the non-SP, a higher expression of c-Myc and TRAIL-receptor DR4.40
154804302004Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells.38
158611842005Chronic lymphocytic leukemic cells exhibit apoptotic signaling via TRAIL-R1.35

Citation

Dessen P

TNFRSF10A (TNF receptor superfamily member 10a)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42605/tnfrsf10a-(tnf-receptor-superfamily-member-10a)