TNFRSF10C (TNF receptor superfamily member 10c)

2003-02-01 Affiliation

Identity

HGNC

TNFRSF10C

LOCATION

8p21.3

LOCUSID

8794

ALIAS

CD263,DCR1,DCR1-TNFR,LIT,TRAIL-R3,TRAILR3,TRID

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8794
MIM: 603613
HGNC: 11906
Ensembl: ENSG00000173535

Variants:

dbSNP: 8794
ClinVar: 8794
TCGA: ENSG00000173535
COSMIC: TNFRSF10C

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000173535	ENST00000356864	O14798
ENSG00000173535	ENST00000517558	E5RJI1

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Apoptosis	KEGG	ko04210
Natural killer cell mediated cytotoxicity	KEGG	ko04650
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Apoptosis	KEGG	hsa04210
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
TP53 Regulates Transcription of Cell Death Genes	REACTOME	R-HSA-5633008
TP53 Regulates Transcription of Death Receptors and Ligands	REACTOME	R-HSA-6803211

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
16980609	2006	Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2.	86
14999791	2004	Aberrant methylation of trail decoy receptor genes is frequent in multiple tumor types.	45
15538968	2004	Following a TRAIL: update on a ligand and its five receptors.	43
15916713	2005	Surface TRAIL decoy receptor-4 expression is correlated with TRAIL resistance in MCF7 breast cancer cells.	35
15921376	2005	TRAIL decoy receptors mediate resistance of acute myeloid leukemia cells to TRAIL.	35
11844843	2002	Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain.	27
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	27
18590575	2008	Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level.	25
26050621	2016	Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity.	20
18460741	2008	Protein phosphatase and TRAIL receptor genes as new candidate tumor genes on chromosome 8p in prostate cancer.	18

Citation

Dessen P

TNFRSF10C (TNF receptor superfamily member 10c)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42607/tnfrsf10c-(tnf-receptor-superfamily-member-10c)