TNFRSF18 (TNF receptor superfamily member 18)

2003-05-01  

Identity

HGNC
TNFRSF18
LOCATION
1p36.33
LOCUSID
8784
ALIAS
AITR,CD357,ENERGEN,GITR,GITR-D

Other Information

Locus ID:

NCBI: 8784
MIM: 603905
HGNC: 11914
Ensembl: ENSG00000186891

Variants:

dbSNP: 8784
ClinVar: 8784
TCGA: ENSG00000186891
COSMIC: TNFRSF18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186891ENST00000328596Q9Y5U5
ENSG00000186891ENST00000379265Q9Y5U5
ENSG00000186891ENST00000379268Q9Y5U5
ENSG00000186891ENST00000486728J3KT02

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNFs bind their physiological receptorsREACTOMER-HSA-5669034

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
229113972013Activated tumor-infiltrating CD4+ regulatory T cells restrain antitumor immunity in patients with primary or metastatic liver cancer.43
189242132008Tr1 and naturally occurring regulatory T cells induce IgG4 in B cells through GITR/GITR-L interaction, IL-10 and TGF-beta.35
259610572015Glucocorticoid-induced tumour necrosis factor receptor-related protein: a key marker of functional regulatory T cells.33
173608482007Cancer immunoediting by GITR (glucocorticoid-induced TNF-related protein) ligand in humans: NK cell/tumor cell interactions.29
203313782010Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.29
215572102011CD4(+) CD25(low) GITR(+) cells: a novel human CD4(+) T-cell population with regulatory activity.28
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
220281762011Enhancement of anti-tumor immunity through local modulation of CTLA-4 and GITR by dendritic cells.23
191553052009Glucocorticoid-induced tumor necrosis factor receptor-related protein ligand subverts immunosurveillance of acute myeloid leukemia in humans.22
194235402009Common variation in genes related to innate immunity and risk of adult glioma.19

Citation

Dessen P

TNFRSF18 (TNF receptor superfamily member 18)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42617/tnfrsf18-(tnf-receptor-superfamily-member-18)