TNFRSF1A (TNF receptor superfamily member 1A)

2003-02-01  

Identity

HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
CD120a,FPF,TBP1,TNF-R,TNF-R-I,TNF-R55,TNFAR,TNFR1,TNFR55,TNFR60,p55,p55-R,p60
FUSION GENES

Other Information

Locus ID:

NCBI: 7132
MIM: 191190
HGNC: 11916
Ensembl: ENSG00000067182

Variants:

dbSNP: 7132
ClinVar: 7132
TCGA: ENSG00000067182
COSMIC: TNFRSF1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000067182ENST00000162749P19438
ENSG00000067182ENST00000366159P19438
ENSG00000067182ENST00000440083F5H6V7
ENSG00000067182ENST00000534885F5GWJ4
ENSG00000067182ENST00000536194F5H6Z2
ENSG00000067182ENST00000539372F5H8A6
ENSG00000067182ENST00000540022F5H061
ENSG00000067182ENST00000543048F5H4T5
ENSG00000067182ENST00000543995F5H7N1

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Cytokine-cytokine receptor interactionKEGGko04060
mTOR signaling pathwayKEGGko04150
ApoptosisKEGGko04210
Adipocytokine signaling pathwayKEGGko04920
Alzheimer's diseaseKEGGko05010
Amyotrophic lateral sclerosis (ALS)KEGGko05014
MAPK signaling pathwayKEGGhsa04010
Cytokine-cytokine receptor interactionKEGGhsa04060
mTOR signaling pathwayKEGGhsa04150
ApoptosisKEGGhsa04210
Adipocytokine signaling pathwayKEGGhsa04920
Alzheimer's diseaseKEGGhsa05010
Amyotrophic lateral sclerosis (ALS)KEGGhsa05014
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Influenza AKEGGko05164
Influenza AKEGGhsa05164
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNFs bind their physiological receptorsREACTOMER-HSA-5669034
Signal TransductionREACTOMER-HSA-162582
Death Receptor SignallingREACTOMER-HSA-73887
TNF signalingREACTOMER-HSA-75893
TNFR1-induced proapoptotic signalingREACTOMER-HSA-5357786
Insulin resistanceKEGGhsa04931
TNFR1-induced NFkappaB signaling pathwayREACTOMER-HSA-5357956
TNFR1-mediated ceramide productionREACTOMER-HSA-5626978
Regulation of TNFR1 signalingREACTOMER-HSA-5357905
Apoptosis - multiple speciesKEGGko04215
Apoptosis - multiple speciesKEGGhsa04215
Interleukin-10 signalingREACTOMER-HSA-6783783
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10004adalimumabChemicalClinicalAnnotationassociatedPD22480748
PA164713366Tumor necrosis factor alpha (TNF-alpha) inhibitorsChemicalClinicalAnnotationassociatedPD22480748, 24776844, 25311255
PA443434Arthritis, RheumatoidDiseaseClinicalAnnotationassociatedPD22480748, 25311255
PA443815Crohn DiseaseDiseaseClinicalAnnotationassociatedPD24776844
PA446116Inflammatory Bowel DiseasesDiseaseClinicalAnnotationassociatedPD24776844
PA446198Arthritis, PsoriaticDiseaseClinicalAnnotationassociatedPD22480748
PA449515etanerceptChemicalClinicalAnnotationassociatedPD22480748
PA452639infliximabChemicalClinicalAnnotationassociatedPD22480748

References

Pubmed IDYearTitleCitations
128879202003Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes.684
229454162013A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers.361
195259532009Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.291
195259532009Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.291
213935092011The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice.221
176886912007Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1beta and TNFalpha expression profile.181
197412982009The tumor-promoting actions of TNF-alpha involve TNFR1 and IL-17 in ovarian cancer in mice and humans.119
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
228014932012TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis.92
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85

Citation

Dessen P

TNFRSF1A (TNF receptor superfamily member 1A)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42620/tnfrsf1a-(tnf-receptor-superfamily-member-1a)