Identity
HGNC
LOCATION
1p36.22
LOCUSID
ALIAS
CD120b,TBPII,TNF-R-II,TNF-R75,TNFBR,TNFR1B,TNFR2,TNFR80,p75,p75TNFR
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7133
MIM: 191191
HGNC: 11917
Ensembl: ENSG00000028137
Variants:
dbSNP: 7133
ClinVar: 7133
TCGA: ENSG00000028137
COSMIC: TNFRSF1B
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000028137 | ENST00000376259 | P20333 |
| ENSG00000028137 | ENST00000536782 | B5A977 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164713366 | Tumor necrosis factor alpha (TNF-alpha) inhibitors | Chemical | ClinicalAnnotation | associated | PD | 18565259, 22129793, 25537528, 25850964 | |
| PA443434 | Arthritis, Rheumatoid | Disease | ClinicalAnnotation | associated | PD | 18565259, 22129793, 25537528, 25850964 | |
| PA445724 | Spondylitis, Ankylosing | Disease | ClinicalAnnotation | associated | PD | 30075559 | |
| PA449515 | etanercept | Chemical | ClinicalAnnotation | associated | PD | 30075559 | |
| PA452639 | infliximab | Chemical | ClinicalAnnotation | associated | PD | 18565259, 22129793, 25537528, 25850964 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38142915 | 2024 | Microglial TNFR2 signaling regulates the inflammatory response after CNS injury in a sex-specific fashion. | 0 |
| 38341270 | 2024 | Tregs from human blood differentiate into nonlymphoid tissue-resident effector cells upon TNFR2 costimulation. | 0 |
| 38364458 | 2024 | Circulating TNF-RII, IP-10 and HGF are associated with severity of COVID-19 in oncologic patients. | 0 |
| 38382266 | 2024 | Progesterone modulates TNF receptors expression by Jurkat cells cultured with plasma from pregnant women with preeclampsia. | 0 |
| 38474115 | 2024 | TNFRSF1B Gene Variants in Clinicopathological Aspects and Prognosis of Patients with Cutaneous Melanoma. | 0 |
| 38537932 | 2024 | Tumor Necrosis Factor Receptor-2 Signals Clear-Cell Renal Carcinoma Proliferation via Phosphorylated 4E Binding Protein-1 and Mitochondrial Gene Translation. | 0 |
| 38865403 | 2024 | Association of polymorphisms in the TNFA, TNFRSF1A and TNFRSF1B genes with lepromatous leprosy in Western Mexican patients. | 0 |
| 38142915 | 2024 | Microglial TNFR2 signaling regulates the inflammatory response after CNS injury in a sex-specific fashion. | 0 |
| 38341270 | 2024 | Tregs from human blood differentiate into nonlymphoid tissue-resident effector cells upon TNFR2 costimulation. | 0 |
| 38364458 | 2024 | Circulating TNF-RII, IP-10 and HGF are associated with severity of COVID-19 in oncologic patients. | 0 |
| 38382266 | 2024 | Progesterone modulates TNF receptors expression by Jurkat cells cultured with plasma from pregnant women with preeclampsia. | 0 |
| 38474115 | 2024 | TNFRSF1B Gene Variants in Clinicopathological Aspects and Prognosis of Patients with Cutaneous Melanoma. | 0 |
| 38537932 | 2024 | Tumor Necrosis Factor Receptor-2 Signals Clear-Cell Renal Carcinoma Proliferation via Phosphorylated 4E Binding Protein-1 and Mitochondrial Gene Translation. | 0 |
| 38865403 | 2024 | Association of polymorphisms in the TNFA, TNFRSF1A and TNFRSF1B genes with lepromatous leprosy in Western Mexican patients. | 0 |
| 36865537 | 2023 | TNFR2 expression predicts the responses to immune checkpoint inhibitor treatments. | 2 |
Citation
Dessen P
TNFRSF1B (TNF receptor superfamily member 1B)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/42621/tnfrsf1b-(tnf-receptor-superfamily-member-1b)
