CD40 (CD40 molecule)

2003-06-01  

Identity

HGNC
CD40
LOCATION
20q13.12
LOCUSID
958
ALIAS
Bp50,CDW40,TNFRSF5,p50
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 958
MIM: 109535
HGNC: 11919
Ensembl: ENSG00000101017

Variants:

dbSNP: 958
ClinVar: 958
TCGA: ENSG00000101017
COSMIC: CD40

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101017ENST00000372276P25942
ENSG00000101017ENST00000372285P25942
ENSG00000101017ENST00000372285A0A0S2Z3C7
ENSG00000101017ENST00000466205H0YE23
ENSG00000101017ENST00000620709A0A087X1D0

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cell adhesion molecules (CAMs)KEGGko04514
Toll-like receptor signaling pathwayKEGGko04620
AsthmaKEGGko05310
Autoimmune thyroid diseaseKEGGko05320
Systemic lupus erythematosusKEGGko05322
Allograft rejectionKEGGko05330
Primary immunodeficiencyKEGGko05340
Cytokine-cytokine receptor interactionKEGGhsa04060
Cell adhesion molecules (CAMs)KEGGhsa04514
Toll-like receptor signaling pathwayKEGGhsa04620
AsthmaKEGGhsa05310
Autoimmune thyroid diseaseKEGGhsa05320
Systemic lupus erythematosusKEGGhsa05322
Allograft rejectionKEGGhsa05330
Primary immunodeficiencyKEGGhsa05340
Viral myocarditisKEGGhsa05416
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
MalariaKEGGko05144
MalariaKEGGhsa05144
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwayREACTOMER-HSA-5676594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
368280132024CD68 Antigen and Cerebral Aneurysms: A Case-Control Study.0
381113342024CD40 is expressed in the subsets of endothelial cells undergoing partial endothelial-mesenchymal transition in tumor microenvironment.1
368280132024CD68 Antigen and Cerebral Aneurysms: A Case-Control Study.0
381113342024CD40 is expressed in the subsets of endothelial cells undergoing partial endothelial-mesenchymal transition in tumor microenvironment.1
365200442023Boosting of tau protein aggregation by CD40 and CD48 gene expression in Alzheimer's disease.1
372947072023CD40 Upregulation in the Retina of Patients With Diabetic Retinopathy: Association With TRAF2/TRAF6 Upregulation and Inflammatory Molecule Expression.1
376911212023Impact of CD40 gene polymorphisms on the risk of cervical squamous cell carcinoma: a case-control study.0
377288542023Platelet factor 4 (PF4) induces cluster of differentiation 40 (CD40) expression in human aortic endothelial cells (HAECs) through the SIRT1/NF-κB/p65 signaling pathway.1
378801782023Allele-specific protein binding within the CD40 locus in human synovial fibroblasts and immune cells.0
380515412023A genetic variant in the CD40 gene is related to HBV infection in the Chinese Han population.0
365200442023Boosting of tau protein aggregation by CD40 and CD48 gene expression in Alzheimer's disease.1
372947072023CD40 Upregulation in the Retina of Patients With Diabetic Retinopathy: Association With TRAF2/TRAF6 Upregulation and Inflammatory Molecule Expression.1
376911212023Impact of CD40 gene polymorphisms on the risk of cervical squamous cell carcinoma: a case-control study.0
377288542023Platelet factor 4 (PF4) induces cluster of differentiation 40 (CD40) expression in human aortic endothelial cells (HAECs) through the SIRT1/NF-κB/p65 signaling pathway.1
378801782023Allele-specific protein binding within the CD40 locus in human synovial fibroblasts and immune cells.0

Citation

Dessen P

CD40 (CD40 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42627