TNFSF13 (TNF superfamily member 13)

2003-06-01  

Identity

HGNC
LOCATION
17p13.1
LOCUSID
ALIAS
APRIL,CD256,TALL-2,TALL2,TNLG7B,TRDL-1,UNQ383/PRO715,ZTNF2
FUSION GENES

Other Information

Locus ID:

NCBI: 8741
MIM: 604472
HGNC: 11928
Ensembl: ENSG00000161955

Variants:

dbSNP: 8741
ClinVar: 8741
TCGA: ENSG00000161955
COSMIC: TNFSF13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161955ENST00000338784O75888
ENSG00000161955ENST00000349228O75888
ENSG00000161955ENST00000380535Q2QBA2
ENSG00000161955ENST00000396542O75888
ENSG00000161955ENST00000396545O75888
ENSG00000161955ENST00000436057C9JF68
ENSG00000161955ENST00000438470C9JFN2
ENSG00000161955ENST00000483039K7EJ28
ENSG00000161955ENST00000625791O75888

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNFs bind their physiological receptorsREACTOMER-HSA-5669034
Gene ExpressionREACTOMER-HSA-74160
Regulation of mRNA stability by proteins that bind AU-rich elementsREACTOMER-HSA-450531
HuR (ELAVL1) binds and stabilizes mRNAREACTOMER-HSA-450520

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
121543592002DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL.357
150706972004BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone.146
169143242006BAFF, APRIL and their receptors: structure, function and signaling.116
179427542008TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts.99
158514872005Identification of proteoglycans as the APRIL-specific binding partners.86
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
158271342005The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature.82
145041012004Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway.76
158606722005Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1alpha.76
149781352004Lymphoma B cells evade apoptosis through the TNF family members BAFF/BLyS and APRIL.74

Citation

Dessen P

TNFSF13 (TNF superfamily member 13)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42635/tnfsf13-(tnf-superfamily-member-13)