Identity
HGNC
LOCATION
13q33.3
LOCUSID
ALIAS
BAFF,BLYS,CD257,DTL,TALL-1,TALL1,THANK,TNFSF20,TNLG7A,ZTNF4
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10673
MIM: 603969
HGNC: 11929
Ensembl: ENSG00000102524
Variants:
dbSNP: 10673
ClinVar: 10673
TCGA: ENSG00000102524
COSMIC: TNFSF13B
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000102524 | ENST00000375887 | Q9Y275 |
| ENSG00000102524 | ENST00000375887 | A0A0U5J7Q1 |
| ENSG00000102524 | ENST00000430559 | Q9Y275 |
| ENSG00000102524 | ENST00000542136 | Q9Y275 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA128406956 | fluorouracil | Chemical | VariantAnnotation | not associated | PD | ||
| PA166114904 | belimumab | Chemical | LabelAnnotation | associated | |||
| PA443560 | Breast Neoplasms | Disease | VariantAnnotation | not associated | PD | ||
| PA444773 | Leukopenia | Disease | VariantAnnotation | not associated | PD | ||
| PA445113 | Neutropenia | Disease | VariantAnnotation | not associated | PD | ||
| PA449165 | cyclophosphamide | Chemical | VariantAnnotation | not associated | PD | ||
| PA449476 | epirubicin | Chemical | VariantAnnotation | not associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38329469 | 2024 | Correlation Between B-Cell Activating Factor of the Tumor Necrosis Factor Family Level in Serum and Immune Inflammation in Patients with Neuropsychiatric Systemic Lupus Erythematosus and its Clinical Value. | 0 |
| 38469292 | 2024 | An unappreciated cell survival-independent role for BAFF initiating chronic lymphocytic leukemia. | 0 |
| 38557386 | 2024 | [Research advances on B-cell activating factor and its targeted agents in inflammatory bowel disease]. | 0 |
| 38600356 | 2024 | An IL-1β-driven neutrophil-stromal cell axis fosters a BAFF-rich protumor microenvironment in individuals with multiple myeloma. | 1 |
| 38329469 | 2024 | Correlation Between B-Cell Activating Factor of the Tumor Necrosis Factor Family Level in Serum and Immune Inflammation in Patients with Neuropsychiatric Systemic Lupus Erythematosus and its Clinical Value. | 0 |
| 38469292 | 2024 | An unappreciated cell survival-independent role for BAFF initiating chronic lymphocytic leukemia. | 0 |
| 38557386 | 2024 | [Research advances on B-cell activating factor and its targeted agents in inflammatory bowel disease]. | 0 |
| 38600356 | 2024 | An IL-1β-driven neutrophil-stromal cell axis fosters a BAFF-rich protumor microenvironment in individuals with multiple myeloma. | 1 |
| 35689637 | 2023 | Subclinical atherosclerosis profiles in rheumatoid arthritis and primary Sjögren's syndrome: the impact of BAFF genetic variations. | 1 |
| 36047579 | 2023 | Expression of B-cell activating factor in pediatric patients with immune thrombocytopenia: a single institutional series and review of literature. | 1 |
| 36094336 | 2023 | SLE stratification based on BAFF and IFN-I bioactivity for biologics and implications of BAFF produced by glomeruli in lupus nephritis. | 8 |
| 36481267 | 2023 | Neutrophilic granulocyte-derived B-cell activating factor supports B cells in skin lesions in hidradenitis suppurativa. | 7 |
| 36508294 | 2023 | TNFSF13B rs9514828 gene polymorphism and soluble B cell activating factor levels: Association with apical periodontitis. | 0 |
| 36645607 | 2023 | BAFF Promotes FLS Activation Through BAFFR-Mediated Non-canonical NF-κB Pathway and the Effects of CP-25. | 2 |
| 37083495 | 2023 | Pleiotropic effects of BAFF on the senescence-associated secretome and growth arrest. | 5 |
Citation
Dessen P
TNFSF13B (TNF superfamily member 13b)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/42636/tnfsf13b-(tnf-superfamily-member-13b)
