TNFSF4 (TNF superfamily member 4)

2003-06-01  

Identity

HGNC
TNFSF4
LOCATION
1q25.1
LOCUSID
7292
ALIAS
CD134L,CD252,GP34,OX-40L,OX4OL,TNLG2B,TXGP1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7292
MIM: 603594
HGNC: 11934
Ensembl: ENSG00000117586

Variants:

dbSNP: 7292
ClinVar: 7292
TCGA: ENSG00000117586
COSMIC: TNFSF4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117586ENST00000281834P23510
ENSG00000117586ENST00000281834A0A024R937
ENSG00000117586ENST00000367718P23510

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNFs bind their physiological receptorsREACTOMER-HSA-5669034

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
162757602005TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand.345
198381932009Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.332
157505942005Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility.89
157505942005Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility.89
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
180592672008Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus.84
180600342007In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation.83
169241082006OX40 ligand shuts down IL-10-producing regulatory T cells.74
153561172004Cross-talk between activated human NK cells and CD4+ T cells via OX40-OX40 ligand interactions.72
176662132007Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation.70

Citation

Dessen P

TNFSF4 (TNF superfamily member 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42640/tnfsf4-(tnf-superfamily-member-4)