TNPO1 (transportin 1)

2003-05-01  

Identity

HGNC
TNPO1
LOCATION
5q13.2
LOCUSID
3842
ALIAS
IPO2,KPNB2,MIP,MIP1,TRN
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3842
MIM: 602901
HGNC: 6401
Ensembl: ENSG00000083312

Variants:

dbSNP: 3842
ClinVar: 3842
TCGA: ENSG00000083312
COSMIC: TNPO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000083312ENST00000337273Q92973
ENSG00000083312ENST00000337273A0A024RAM0
ENSG00000083312ENST00000506351Q92973
ENSG00000083312ENST00000520850E7EW37
ENSG00000083312ENST00000523768Q92973
ENSG00000083312ENST00000605210S4R398

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Intraflagellar transportREACTOMER-HSA-5620924
Gene ExpressionREACTOMER-HSA-74160
Regulation of mRNA stability by proteins that bind AU-rich elementsREACTOMER-HSA-450531
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNAREACTOMER-HSA-450513

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
206066252010ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import.282
229681702012Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS.93
212852452011Localization of retinitis pigmentosa 2 to cilia is regulated by Importin beta2.48
296775132018Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.45
191246062009RNA-regulated interaction of transportin-1 and exportin-5 with the double-stranded RNA-binding domain regulates nucleocytoplasmic shuttling of ADAR1.44
233333092013Redox-dependent control of FOXO/DAF-16 by transportin-1.44
155076042004The l2 minor capsid protein of human papillomavirus type 16 interacts with a network of nuclear import receptors.41
247800992014Transportin-1 and Transportin-2: protein nuclear import and beyond.30
179367042007Structural basis for substrate recognition and dissociation by human transportin 1.28
228428752012Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations.27

Citation

Dessen P

TNPO1 (transportin 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42648/tnpo1-(transportin-1)