TOMM20 (translocase of outer mitochondrial membrane 20)

2003-10-01  

Identity

HGNC
LOCATION
1q42.3
LOCUSID
ALIAS
MAS20,MOM19,TOM20
FUSION GENES

Other Information

Locus ID:

NCBI: 9804
MIM: 601848
HGNC: 20947
Ensembl: ENSG00000173726

Variants:

dbSNP: 9804
ClinVar: 9804
TCGA: ENSG00000173726
COSMIC: TOMM20

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173726ENST00000366607Q15388
ENSG00000173726ENST00000366607A0A024R3W2

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Mitochondrial protein importREACTOMER-HSA-1268020
MitophagyREACTOMER-HSA-5205647
Pink/Parkin Mediated MitophagyREACTOMER-HSA-5205685
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
293959202018TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca2+ Transfer.14
217717902011Interaction between the human mitochondrial import receptors Tom20 and Tom70 in vitro suggests a chaperone displacement mechanism.13
146991152004Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity.11
266151362015Mitochondrial Metabolism as a Treatment Target in Anaplastic Thyroid Cancer.9
231657762013Immunocytochemical localization of the translocase of the outer mitochondrial membrane (Tom20) in the human cochlea.8
275039092016Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease.8
292481322017Mitochondrial and glycolytic metabolic compartmentalization in diffuse large B-cell lymphoma.8
292481332017Hodgkin lymphoma: A complex metabolic ecosystem with glycolytic reprogramming of the tumor microenvironment.8
119139752002Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins.6

Citation

Dessen P

TOMM20 (translocase of outer mitochondrial membrane 20)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/42655/tomm20-(translocase-of-outer-mitochondrial-membrane-20)