FCMR (Fc fragment of IgM receptor)

2003-11-01  

Identity

HGNC
FCMR
LOCATION
1q32.1
LOCUSID
9214
ALIAS
FAIM3,TOSO
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9214
MIM: 606015
HGNC: 14315
Ensembl: ENSG00000162894

Variants:

dbSNP: 9214
ClinVar: 9214
TCGA: ENSG00000162894
COSMIC: FCMR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162894ENST00000367091O60667
ENSG00000162894ENST00000442471O60667
ENSG00000162894ENST00000463473E9PQG1
ENSG00000162894ENST00000525793E9PN59
ENSG00000162894ENST00000529560E9PMT7
ENSG00000162894ENST00000530505E9PPV1
ENSG00000162894ENST00000628511O60667

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
198583242009Identity of the elusive IgM Fc receptor (FcmuR) in humans.61
200424542010Identification of TOSO/FAIM3 as an Fc receptor for IgM.40
219087322011TOSO, the Fcmicro receptor, is highly expressed on chronic lymphocytic leukemia B cells, internalizes upon IgM binding, shuttles to the lysosome, and is downregulated in response to TLR activation.32
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
216132572011Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitination.17
187086282008Overexpression of TOSO in CLL is triggered by B-cell receptor signaling and associated with progressive disease.16
184346112008SAGE analysis demonstrates increased expression of TOSO contributing to Fas-mediated resistance in CLL.14
204104972010IgM, Fc mu Rs, and malarial immune evasion.13
226752002012Toso, a functional IgM receptor, is regulated by IL-2 in T and NK cells.12
219084242011Enhanced levels of both the membrane-bound and soluble forms of IgM Fc receptor (FcμR) in patients with chronic lymphocytic leukemia.10

Citation

Dessen P

FCMR (Fc fragment of IgM receptor)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42664/fcmr-(fc-fragment-of-igm-receptor)