TP53I3 (tumor protein p53 inducible protein 3)

2003-02-01  

Identity

HGNC
TP53I3
LOCATION
2p23.3
LOCUSID
9540
ALIAS
PIG3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9540
MIM: 605171
HGNC: 19373
Ensembl: ENSG00000115129

Variants:

dbSNP: 9540
ClinVar: 9540
TCGA: ENSG00000115129
COSMIC: TP53I3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115129ENST00000238721Q53FA7
ENSG00000115129ENST00000335934Q53FA7
ENSG00000115129ENST00000407482Q53FA7
ENSG00000115129ENST00000413037H7BZH6

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
p53 signaling pathwayKEGGko04115
p53 signaling pathwayKEGGhsa04115
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Transcription of Cell Death GenesREACTOMER-HSA-5633008
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertainREACTOMER-HSA-6803205

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
302818782018p53-inducible gene 3 promotes cell migration and invasion by activating the FAK/Src pathway in lung adenocarcinoma.12
303344112018PIG3 suppresses gastric cancer proliferation by regulating p53- mediated apoptosis.5
302818782018p53-inducible gene 3 promotes cell migration and invasion by activating the FAK/Src pathway in lung adenocarcinoma.12
303344112018PIG3 suppresses gastric cancer proliferation by regulating p53- mediated apoptosis.5
282591832017PIG3 promotes NSCLC cell mitotic progression and is associated with poor prognosis of NSCLC patients.11
283513262017Suppression of p53-inducible gene 3 is significant for glioblastoma progression and predicts poor patient prognosis.6
282591832017PIG3 promotes NSCLC cell mitotic progression and is associated with poor prognosis of NSCLC patients.11
283513262017Suppression of p53-inducible gene 3 is significant for glioblastoma progression and predicts poor patient prognosis.6
264644642016Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination.35
264727232016Methyl methanesulfonate induces necroptosis in human lung adenoma A549 cells through the PIG-3-reactive oxygen species pathway.10
270290702016Loss of PIG3 increases HIF-1α level by promoting protein synthesis via mTOR pathway in renal cell carcinoma cells.3
264644642016Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination.35
264727232016Methyl methanesulfonate induces necroptosis in human lung adenoma A549 cells through the PIG-3-reactive oxygen species pathway.10
270290702016Loss of PIG3 increases HIF-1α level by promoting protein synthesis via mTOR pathway in renal cell carcinoma cells.3
261337722015PIG3 plays an oncogenic role in papillary thyroid cancer by activating the PI3K/AKT/PTEN pathway.19

Citation

Dessen P

TP53I3 (tumor protein p53 inducible protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42670/tp53i3-(tumor-protein-p53-inducible-protein-3)