Identity
HGNC
LOCATION
15q22.2
LOCUSID
ALIAS
C15orf13,CMD1Y,CMH3,HEL-S-265,HTM-alpha,LVNC9,TMSA
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7168
MIM: 191010
HGNC: 12010
Ensembl: ENSG00000140416
Variants:
dbSNP: 7168
ClinVar: 7168
TCGA: ENSG00000140416
COSMIC: TPM1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA162375571 | ACTC1 | Gene | DataAnnotation | associated | |||
| PA231 | LMNA | Gene | DataAnnotation | associated | |||
| PA28707 | GLA | Gene | DataAnnotation | associated | |||
| PA31351 | MYBPC3 | Gene | DataAnnotation | associated | |||
| PA31374 | MYH7 | Gene | DataAnnotation | associated | |||
| PA31380 | MYL2 | Gene | DataAnnotation | associated | |||
| PA31381 | MYL3 | Gene | DataAnnotation | associated | |||
| PA33752 | PRKAG2 | Gene | DataAnnotation | associated | |||
| PA36636 | TNNI3 | Gene | DataAnnotation | associated | |||
| PA36638 | TNNT2 | Gene | DataAnnotation | associated | |||
| PA443632 | Cardiomyopathy, Dilated | Disease | DataAnnotation | associated | |||
| PA443633 | Cardiomyopathy, Hypertrophic | Disease | DataAnnotation | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33642254 | 2022 | Genotype-phenotype correlations in hypertrophic cardiomyopathy: a multicenter study in Portugal and Spain of the TPM1 p.Arg21Leu variant. | 4 |
| 34850589 | 2022 | The prognostic value of TPM1-4 in hepatocellular carcinoma. | 11 |
| 34942531 | 2022 | The effects of the tropomyosin cardiomyopathy mutations on the calcium regulation of actin-myosin interaction in the atrium and ventricle differ. | 1 |
| 35029218 | 2022 | Identification of a novel missense mutation in the TPM1 gene via exome sequencing in a Chinese family with dilated cardiomyopathy: A case report and literature review. | 2 |
| 35243414 | 2022 | Genetic resiliency associated with dominant lethal TPM1 mutation causing atrial septal defect with high heritability. | 2 |
| 35857351 | 2022 | MYC-Induced Upregulation of Lncrna ELFN1-AS1 Contributes to Tumor Growth in Colorectal Cancer via Epigenetically Silencing TPM1. | 5 |
| 36555368 | 2022 | Impact of Troponin in Cardiomyopathy Development Caused by Mutations in Tropomyosin. | 2 |
| 33642254 | 2022 | Genotype-phenotype correlations in hypertrophic cardiomyopathy: a multicenter study in Portugal and Spain of the TPM1 p.Arg21Leu variant. | 4 |
| 34850589 | 2022 | The prognostic value of TPM1-4 in hepatocellular carcinoma. | 11 |
| 34942531 | 2022 | The effects of the tropomyosin cardiomyopathy mutations on the calcium regulation of actin-myosin interaction in the atrium and ventricle differ. | 1 |
| 35029218 | 2022 | Identification of a novel missense mutation in the TPM1 gene via exome sequencing in a Chinese family with dilated cardiomyopathy: A case report and literature review. | 2 |
| 35243414 | 2022 | Genetic resiliency associated with dominant lethal TPM1 mutation causing atrial septal defect with high heritability. | 2 |
| 35857351 | 2022 | MYC-Induced Upregulation of Lncrna ELFN1-AS1 Contributes to Tumor Growth in Colorectal Cancer via Epigenetically Silencing TPM1. | 5 |
| 36555368 | 2022 | Impact of Troponin in Cardiomyopathy Development Caused by Mutations in Tropomyosin. | 2 |
| 32882290 | 2021 | The effect of tropomyosin variants on cardiomyocyte function and structure that underlie different clinical cardiomyopathy phenotypes. | 7 |
Citation
Dessen P
TPM1 (tropomyosin 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/42679/tpm1-(tropomyosin-1)
