TPO (thyroid peroxidase)

2003-02-01  

Identity

HGNC
LOCATION
2p25.3
LOCUSID
ALIAS
MSA,TDH2A,TPX
FUSION GENES

Other Information

Locus ID:

NCBI: 7173
MIM: 606765
HGNC: 12015
Ensembl: ENSG00000115705

Variants:

dbSNP: 7173
ClinVar: 7173
TCGA: ENSG00000115705
COSMIC: TPO

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115705ENST00000329066P07202
ENSG00000115705ENST00000345913P07202
ENSG00000115705ENST00000346956P07202
ENSG00000115705ENST00000382198P07202
ENSG00000115705ENST00000382201P07202
ENSG00000115705ENST00000382269E9PFM6
ENSG00000115705ENST00000422464H0Y6H4
ENSG00000115705ENST00000423320C9J511
ENSG00000115705ENST00000446278H7C1F5
ENSG00000115705ENST00000469607H7C5B6
ENSG00000115705ENST00000539820E9PFM6

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
Tyrosine metabolismKEGGko00350
Autoimmune thyroid diseaseKEGGko05320
Tyrosine metabolismKEGGhsa00350
Autoimmune thyroid diseaseKEGGhsa05320
Metabolic pathwaysKEGGhsa01100
Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxineKEGGhsa_M00043
Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxineKEGGM00043
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Amine-derived hormonesREACTOMER-HSA-209776
Thyroxine biosynthesisREACTOMER-HSA-209968

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
384828222024Disulfide Bonds of Thyroid Peroxidase Are Critical Elements for Subcellular Localization, Proteasome-Dependent Degradation, and Enzyme Activity.0
385422862024Is There a Link between Thyroid Peroxidase Gene Promoter Polymorphisms and Autoimmune Thyroiditis in the Polish Population?0
384828222024Disulfide Bonds of Thyroid Peroxidase Are Critical Elements for Subcellular Localization, Proteasome-Dependent Degradation, and Enzyme Activity.0
385422862024Is There a Link between Thyroid Peroxidase Gene Promoter Polymorphisms and Autoimmune Thyroiditis in the Polish Population?0
365375742023Cryo-electron microscopy structures of human thyroid peroxidase (TPO) in complex with TPO antibodies.2
367377532023Variants in TPO rs2048722, PTCSC2 rs925489 and SEMA4G rs4919510 affect thyroid carcinoma susceptibility risk.0
369895262023Longitudinal Associations Between TPO Gene Variants and Thyroid Peroxidase Antibody Seroconversion in a Population-Based Study: Tehran Thyroid Study.0
374077002023TPO as an indicator of lymph node metastasis and recurrence in papillary thyroid carcinoma.2
377809992023Homozygous Mutations in Thyroid Peroxidase (TPO) in Hypothyroidism with Intellectual Disability, Developmental Delay, and Hearing and Ocular Anomalies in Two Families: Severe Manifestation of Untreated TPO-deficiency Poses a Diagnostic Dilemma.0
365375742023Cryo-electron microscopy structures of human thyroid peroxidase (TPO) in complex with TPO antibodies.2
367377532023Variants in TPO rs2048722, PTCSC2 rs925489 and SEMA4G rs4919510 affect thyroid carcinoma susceptibility risk.0
369895262023Longitudinal Associations Between TPO Gene Variants and Thyroid Peroxidase Antibody Seroconversion in a Population-Based Study: Tehran Thyroid Study.0
374077002023TPO as an indicator of lymph node metastasis and recurrence in papillary thyroid carcinoma.2
377809992023Homozygous Mutations in Thyroid Peroxidase (TPO) in Hypothyroidism with Intellectual Disability, Developmental Delay, and Hearing and Ocular Anomalies in Two Families: Severe Manifestation of Untreated TPO-deficiency Poses a Diagnostic Dilemma.0
348966202022TSH stimulation of human thyroglobulin and thyroid peroxidase gene transcription is partially dependent on internalization.0

Citation

Dessen P

TPO (thyroid peroxidase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42681/tpo-(thyroid-peroxidase)