TRAF1 (TNF receptor associated factor 1)

2003-05-01  

Identity

HGNC
LOCATION
9q33.2
LOCUSID
ALIAS
EBI6,MGC:10353
FUSION GENES

Other Information

Locus ID:

NCBI: 7185
MIM: 601711
HGNC: 12031
Ensembl: ENSG00000056558

Variants:

dbSNP: 7185
ClinVar: 7185
TCGA: ENSG00000056558
COSMIC: TRAF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000056558ENST00000373887Q13077
ENSG00000056558ENST00000540010Q13077
ENSG00000056558ENST00000546084Q13077

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
ApoptosisKEGGko04210
Small cell lung cancerKEGGko05222
ApoptosisKEGGhsa04210
Pathways in cancerKEGGhsa05200
Small cell lung cancerKEGGhsa05222
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Signal TransductionREACTOMER-HSA-162582
Death Receptor SignallingREACTOMER-HSA-73887
TNF signalingREACTOMER-HSA-75893
TNFR1-induced NFkappaB signaling pathwayREACTOMER-HSA-5357956
Regulation of TNFR1 signalingREACTOMER-HSA-5357905

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10004adalimumabChemicalClinicalAnnotationassociatedPD23007924
PA164713366Tumor necrosis factor alpha (TNF-alpha) inhibitorsChemicalClinicalAnnotationassociatedPD23007924
PA443434Arthritis, RheumatoidDiseaseClinicalAnnotationassociatedPD23007924
PA449515etanerceptChemicalClinicalAnnotationassociatedPD23007924
PA452639infliximabChemicalClinicalAnnotationassociatedPD23007924

References

Pubmed IDYearTitleCitations
381172132024Association between TRAF1/C5 Gene Polymorphisms and IgA Vasculitis in Chinese Children.0
385835982024Lower levels of TRAF1 in Brodmann's area 24, but not 46, in bipolar disorders are not detectable in major depressive disorders.0
381172132024Association between TRAF1/C5 Gene Polymorphisms and IgA Vasculitis in Chinese Children.0
385835982024Lower levels of TRAF1 in Brodmann's area 24, but not 46, in bipolar disorders are not detectable in major depressive disorders.0
366372232023Cutting Edge: Negative Regulation of Inflammasome Activation by TRAF1 Can Limit Gout.2
366372232023Cutting Edge: Negative Regulation of Inflammasome Activation by TRAF1 Can Limit Gout.2
351940312022FXR1 can bind with the CFIm25/CFIm68 complex and promote the progression of urothelial carcinoma of the bladder by stabilizing TRAF1 mRNA.8
355384752022N(6)-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma.32
362162072022Knockdown of circ_0038467 alleviates lipopolysaccharides-induced 16HBE cell injury by regulating the miR-545-3p/TRAF1 axis in neonatal pneumonia.0
351940312022FXR1 can bind with the CFIm25/CFIm68 complex and promote the progression of urothelial carcinoma of the bladder by stabilizing TRAF1 mRNA.8
355384752022N(6)-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma.32
362162072022Knockdown of circ_0038467 alleviates lipopolysaccharides-induced 16HBE cell injury by regulating the miR-545-3p/TRAF1 axis in neonatal pneumonia.0
329591872021Weighted gene co-expression network analysis identifies RHOH and TRAF1 as key candidate genes for psoriatic arthritis.2
343639262021A genetic variant in the TRAF1/C5 gene lead susceptibility to active pulmonary tuberculosis by decreased TNF-α levels.2
329591872021Weighted gene co-expression network analysis identifies RHOH and TRAF1 as key candidate genes for psoriatic arthritis.2

Citation

Dessen P

TRAF1 (TNF receptor associated factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42686/traf1-(tnf-receptor-associated-factor-1)