Identity
HGNC
LOCATION
9q33.2
LOCUSID
ALIAS
EBI6,MGC:10353
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7185
MIM: 601711
HGNC: 12031
Ensembl: ENSG00000056558
Variants:
dbSNP: 7185
ClinVar: 7185
TCGA: ENSG00000056558
COSMIC: TRAF1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000056558 | ENST00000373887 | Q13077 |
| ENSG00000056558 | ENST00000540010 | Q13077 |
| ENSG00000056558 | ENST00000546084 | Q13077 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10004 | adalimumab | Chemical | ClinicalAnnotation | associated | PD | 23007924 | |
| PA164713366 | Tumor necrosis factor alpha (TNF-alpha) inhibitors | Chemical | ClinicalAnnotation | associated | PD | 23007924 | |
| PA443434 | Arthritis, Rheumatoid | Disease | ClinicalAnnotation | associated | PD | 23007924 | |
| PA449515 | etanercept | Chemical | ClinicalAnnotation | associated | PD | 23007924 | |
| PA452639 | infliximab | Chemical | ClinicalAnnotation | associated | PD | 23007924 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38117213 | 2024 | Association between TRAF1/C5 Gene Polymorphisms and IgA Vasculitis in Chinese Children. | 0 |
| 38583598 | 2024 | Lower levels of TRAF1 in Brodmann's area 24, but not 46, in bipolar disorders are not detectable in major depressive disorders. | 0 |
| 38117213 | 2024 | Association between TRAF1/C5 Gene Polymorphisms and IgA Vasculitis in Chinese Children. | 0 |
| 38583598 | 2024 | Lower levels of TRAF1 in Brodmann's area 24, but not 46, in bipolar disorders are not detectable in major depressive disorders. | 0 |
| 36637223 | 2023 | Cutting Edge: Negative Regulation of Inflammasome Activation by TRAF1 Can Limit Gout. | 2 |
| 36637223 | 2023 | Cutting Edge: Negative Regulation of Inflammasome Activation by TRAF1 Can Limit Gout. | 2 |
| 35194031 | 2022 | FXR1 can bind with the CFIm25/CFIm68 complex and promote the progression of urothelial carcinoma of the bladder by stabilizing TRAF1 mRNA. | 8 |
| 35538475 | 2022 | N(6)-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma. | 32 |
| 36216207 | 2022 | Knockdown of circ_0038467 alleviates lipopolysaccharides-induced 16HBE cell injury by regulating the miR-545-3p/TRAF1 axis in neonatal pneumonia. | 0 |
| 35194031 | 2022 | FXR1 can bind with the CFIm25/CFIm68 complex and promote the progression of urothelial carcinoma of the bladder by stabilizing TRAF1 mRNA. | 8 |
| 35538475 | 2022 | N(6)-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma. | 32 |
| 36216207 | 2022 | Knockdown of circ_0038467 alleviates lipopolysaccharides-induced 16HBE cell injury by regulating the miR-545-3p/TRAF1 axis in neonatal pneumonia. | 0 |
| 32959187 | 2021 | Weighted gene co-expression network analysis identifies RHOH and TRAF1 as key candidate genes for psoriatic arthritis. | 2 |
| 34363926 | 2021 | A genetic variant in the TRAF1/C5 gene lead susceptibility to active pulmonary tuberculosis by decreased TNF-α levels. | 2 |
| 32959187 | 2021 | Weighted gene co-expression network analysis identifies RHOH and TRAF1 as key candidate genes for psoriatic arthritis. | 2 |
Citation
Dessen P
TRAF1 (TNF receptor associated factor 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/42686/traf1-(tnf-receptor-associated-factor-1)
