TRAF5 (TNF receptor associated factor 5)

2003-08-01  

Identity

HGNC
LOCATION
1q32.3
LOCUSID
ALIAS
MGC:39780,RNF84
FUSION GENES

Other Information

Locus ID:

NCBI: 7188
MIM: 602356
HGNC: 12035
Ensembl: ENSG00000082512

Variants:

dbSNP: 7188
ClinVar: 7188
TCGA: ENSG00000082512
COSMIC: TRAF5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000082512ENST00000261464O00463
ENSG00000082512ENST00000336184O00463
ENSG00000082512ENST00000367004O00463

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Small cell lung cancerKEGGko05222
Pathways in cancerKEGGhsa05200
Small cell lung cancerKEGGhsa05222
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
386420792024Tumor necrosis factor receptor-associated factor 5 protects against intimal hyperplasia by regulation of macrophage polarization via directly targeting PPARγ.0
386420792024Tumor necrosis factor receptor-associated factor 5 protects against intimal hyperplasia by regulation of macrophage polarization via directly targeting PPARγ.0
373664262023Silencing of TRAF5 enhances necroptosis in hepatocellular carcinoma by inhibiting LTBR-mediated NF-κB signaling.2
373664262023Silencing of TRAF5 enhances necroptosis in hepatocellular carcinoma by inhibiting LTBR-mediated NF-κB signaling.2
349833612022LncRNA HCG18 upregulates TRAF4/TRAF5 to facilitate proliferation, migration and EMT of epithelial ovarian cancer by targeting miR-29a/b.9
349833612022LncRNA HCG18 upregulates TRAF4/TRAF5 to facilitate proliferation, migration and EMT of epithelial ovarian cancer by targeting miR-29a/b.9
335551972021Tumor-Associated Macrophages Promote Oxaliplatin Resistance via METTL3-Mediated m(6)A of TRAF5 and Necroptosis in Colorectal Cancer.37
339979372021Single nucleotide polymorphisms of TRAF2 and TRAF5 gene in ankylosing spondylitis: a case-control study.0
340212682021Association of methylation level and transcript level in TRAF5 gene with ankylosing spondylitis: a case-control study.1
335551972021Tumor-Associated Macrophages Promote Oxaliplatin Resistance via METTL3-Mediated m(6)A of TRAF5 and Necroptosis in Colorectal Cancer.37
339979372021Single nucleotide polymorphisms of TRAF2 and TRAF5 gene in ankylosing spondylitis: a case-control study.0
340212682021Association of methylation level and transcript level in TRAF5 gene with ankylosing spondylitis: a case-control study.1
316560432020LINC00467 promotes cell proliferation and metastasis by binding with IGF2BP3 to enhance the mRNA stability of TRAF5 in hepatocellular carcinoma.25
316688092020TRAF5 promotes plasmacytoid dendritic cell development from bone marrow progenitors.0
329119262020TRAF5 promotes the occurrence and development of colon cancer via the activation of PI3K/AKT/NF-κB signaling pathways.4

Citation

Dessen P

TRAF5 (TNF receptor associated factor 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42687/traf5-(tnf-receptor-associated-factor-5)