TRIM32 (tripartite motif containing 32)

2003-05-01  

Identity

HGNC
TRIM32
LOCATION
9q33.1
LOCUSID
22954
ALIAS
BBS11,HT2A,LGMD2H,LGMDR8,TATIP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 22954
MIM: 602290
HGNC: 16380
Ensembl: ENSG00000119401

Variants:

dbSNP: 22954
ClinVar: 22954
TCGA: ENSG00000119401
COSMIC: TRIM32

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119401ENST00000373983Q13049
ENSG00000119401ENST00000373983A0A024R843
ENSG00000119401ENST00000411410Q5JVY0
ENSG00000119401ENST00000450136Q13049
ENSG00000119401ENST00000450136A0A024R843

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Innate Immune SystemREACTOMER-HSA-168249
Cytosolic sensors of pathogen-associated DNAREACTOMER-HSA-1834949
Regulation of innate immune responses to cytosolic DNAREACTOMER-HSA-3134975

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
377345662024CDK2-activated TRIM32 phosphorylation and nuclear translocation promotes radioresistance in triple-negative breast cancer.3
383175202024Enhanced translocation of TRIM32 to mitochondria sensitizes dopaminergic neuronal cells to apoptosis during stress conditions in Parkinson's disease.1
387171132024Degradation of TRIM32 is induced by RTA for Kaposi's sarcoma-associated herpesvirus lytic replication.0
388229012024Adipose stem cell‑derived exosomes promote high glucose-induced wound healing by regulating the TRIM32/STING axis.0
377345662024CDK2-activated TRIM32 phosphorylation and nuclear translocation promotes radioresistance in triple-negative breast cancer.3
383175202024Enhanced translocation of TRIM32 to mitochondria sensitizes dopaminergic neuronal cells to apoptosis during stress conditions in Parkinson's disease.1
387171132024Degradation of TRIM32 is induced by RTA for Kaposi's sarcoma-associated herpesvirus lytic replication.0
388229012024Adipose stem cell‑derived exosomes promote high glucose-induced wound healing by regulating the TRIM32/STING axis.0
376269152023Tripartite Motif-Containing Protein 32 (TRIM32): What Does It Do for Skeletal Muscle?0
376400022023TRIM32 promotes oral squamous cell carcinoma progression by enhancing FBP2 ubiquitination and degradation.0
379796632023RHBDF1 deficiency suppresses melanoma glycolysis and enhances efficacy of immunotherapy by facilitating glucose-6-phosphate isomerase degradation via TRIM32.0
376269152023Tripartite Motif-Containing Protein 32 (TRIM32): What Does It Do for Skeletal Muscle?0
376400022023TRIM32 promotes oral squamous cell carcinoma progression by enhancing FBP2 ubiquitination and degradation.0
379796632023RHBDF1 deficiency suppresses melanoma glycolysis and enhances efficacy of immunotherapy by facilitating glucose-6-phosphate isomerase degradation via TRIM32.0
347839422022TRIM32 Inhibition Attenuates Apoptosis, Oxidative Stress, and Inflammatory Injury in Podocytes Induced by High Glucose by Modulating the Akt/GSK-3β/Nrf2 Pathway.3

Citation

Dessen P

TRIM32 (tripartite motif containing 32)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42702/trim32-(tripartite-motif-containing-32)