TRAIP (TRAF interacting protein)

2003-08-01  

Identity

HGNC
TRAIP
LOCATION
3p21.31
LOCUSID
10293
ALIAS
RNF206,SCKL9,TRIP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10293
MIM: 605958
HGNC: 30764
Ensembl: ENSG00000183763

Variants:

dbSNP: 10293
ClinVar: 10293
TCGA: ENSG00000183763
COSMIC: TRAIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183763ENST00000331456Q9BWF2
ENSG00000183763ENST00000469027E7ETV1
ENSG00000183763ENST00000473195E7EVC4
ENSG00000183763ENST00000482243E7EW89
ENSG00000183763ENST00000482582E7EN91

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381000272024TRAIP suppressed apoptosis and cell cycle to promote prostate cancer proliferation via TRAF2-PI3K-AKT pathway activation.0
381000272024TRAIP suppressed apoptosis and cell cycle to promote prostate cancer proliferation via TRAF2-PI3K-AKT pathway activation.0
360645762023Silencing TRAIP suppresses cell proliferation and migration/invasion of triple negative breast cancer via RB-E2F signaling and EMT.5
365941632023ZNF212 promotes genomic integrity through direct interaction with TRAIP.0
376048122023TRAIP resolves DNA replication-transcription conflicts during the S-phase of unperturbed cells.1
360645762023Silencing TRAIP suppresses cell proliferation and migration/invasion of triple negative breast cancer via RB-E2F signaling and EMT.5
365941632023ZNF212 promotes genomic integrity through direct interaction with TRAIP.0
376048122023TRAIP resolves DNA replication-transcription conflicts during the S-phase of unperturbed cells.1
333179332021The Ubiquitin Ligase TRAIP: Double-Edged Sword at the Replisome.12
343491172021TRAIP modulates the IGFBP3/AKT pathway to enhance the invasion and proliferation of osteosarcoma by promoting KANK1 degradation.11
333179332021The Ubiquitin Ligase TRAIP: Double-Edged Sword at the Replisome.12
343491172021TRAIP modulates the IGFBP3/AKT pathway to enhance the invasion and proliferation of osteosarcoma by promoting KANK1 degradation.11
319723582020TRAIP promotes malignant behaviors and correlates with poor prognosis in liver cancer.8
319808152020Cooperation of the NEIL3 and Fanconi anemia/BRCA pathways in interstrand crosslink repair.41
326400402020TRIP suppresses cell proliferation and invasion in choroidal melanoma via promoting the proteasomal degradation of Twist1.4

Citation

Dessen P

TRAIP (TRAF interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42705/traip-(traf-interacting-protein)