TUSC3 (tumor suppressor candidate 3)

2003-02-01  

Identity

HGNC
TUSC3
LOCATION
8p22
LOCUSID
7991
ALIAS
D8S1992,M33,MRT22,MRT7,MagT2,N33,OST3A,SLC58A2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7991
MIM: 601385
HGNC: 30242
Ensembl: ENSG00000104723

Variants:

dbSNP: 7991
ClinVar: 7991
TCGA: ENSG00000104723
COSMIC: TUSC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104723ENST00000382020Q13454
ENSG00000104723ENST00000503731Q13454
ENSG00000104723ENST00000506802D6RIY7
ENSG00000104723ENST00000509380D6RA37
ENSG00000104723ENST00000510836D6RDV0
ENSG00000104723ENST00000511783A0A0A0MTC2
ENSG00000104723ENST00000515859D6RDV0

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
N-Glycan biosynthesisKEGGko00510
N-Glycan biosynthesisKEGGhsa00510
Metabolic pathwaysKEGGhsa01100
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
N-glycosylation by oligosaccharyltransferaseKEGGhsa_M00072
N-glycosylation by oligosaccharyltransferaseKEGGM00072
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Miscellaneous transport and binding eventsREACTOMER-HSA-5223345

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
351375202022TUSC3 inhibits cell proliferation and invasion in cervical squamous cell carcinoma via suppression of the AKT signalling pathway.3
362741322022Downregulation of TUSC3 promotes EMT and hepatocellular carcinoma progression through LIPC/AKT axis.2
351375202022TUSC3 inhibits cell proliferation and invasion in cervical squamous cell carcinoma via suppression of the AKT signalling pathway.3
362741322022Downregulation of TUSC3 promotes EMT and hepatocellular carcinoma progression through LIPC/AKT axis.2
315828372020UHRF1-KAT7-mediated regulation of TUSC3 expression via histone methylation/acetylation is critical for the proliferation of colon cancer cells.16
320903522020Tumour suppressor candidate 3 inhibits biological function and increases endoplasmic reticulum stress of melanoma cells WM451 by regulating AKT/GSK3-β/β-catenin pathway.1
323382812020TUSC3 induces drug resistance and cellular stemness via Hedgehog signaling pathway in colorectal cancer.6
326530212020Concentrations of persistent organic pollutants in maternal plasma and epigenome-wide placental DNA methylation.17
315828372020UHRF1-KAT7-mediated regulation of TUSC3 expression via histone methylation/acetylation is critical for the proliferation of colon cancer cells.16
320903522020Tumour suppressor candidate 3 inhibits biological function and increases endoplasmic reticulum stress of melanoma cells WM451 by regulating AKT/GSK3-β/β-catenin pathway.1
323382812020TUSC3 induces drug resistance and cellular stemness via Hedgehog signaling pathway in colorectal cancer.6
326530212020Concentrations of persistent organic pollutants in maternal plasma and epigenome-wide placental DNA methylation.17
289291752018TUSC3: functional duality of a cancer gene.17
300983332018TUSC3 accelerates cancer growth and induces epithelial-mesenchymal transition by upregulating claudin-1 in non-small-cell lung cancer cells.7
301155372018Expression of TUSC3 and its prognostic significance in colorectal cancer.6

Citation

Dessen P

TUSC3 (tumor suppressor candidate 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42732/tusc3-(tumor-suppressor-candidate-3)