UBE2B (ubiquitin conjugating enzyme E2 B)

2003-11-01  

Identity

HGNC
LOCATION
5q31.1
LOCUSID
ALIAS
E2-17kDa,HHR6B,HR6B,RAD6B,UBC2
FUSION GENES

Other Information

Locus ID:

NCBI: 7320
MIM: 179095
HGNC: 12473
Ensembl: ENSG00000119048

Variants:

dbSNP: 7320
ClinVar: 7320
TCGA: ENSG00000119048
COSMIC: UBE2B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119048ENST00000265339P63146
ENSG00000119048ENST00000506787H0YA80
ENSG00000119048ENST00000507277H0Y9V2
ENSG00000119048ENST00000510021D6RDW8

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
DNA RepairREACTOMER-HSA-73894
DNA Damage BypassREACTOMER-HSA-73893
Recognition of DNA damage by PCNA-containing replication complexREACTOMER-HSA-110314
Protein ubiquitinationREACTOMER-HSA-8852135
Synthesis of active ubiquitin: roles of E1 and E2 enzymesREACTOMER-HSA-8866652
E3 ubiquitin ligases ubiquitinate target proteinsREACTOMER-HSA-8866654

References

Pubmed IDYearTitleCitations
203786152010Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.40
183398542008Rad6B is a positive regulator of beta-catenin stabilization.31
183639652008Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks.27
272356752016Up-regulation of miR-455-5p by the TGF-β-SMAD signalling axis promotes the proliferation of oral squamous cancer cells by targeting UBE2B.25
149815452004RAD6B overexpression confers chemoresistance: RAD6 expression during cell cycle and its redistribution to chromatin during DNA damage-induced response.21
215497152011Symmetry and asymmetry of the RING-RING dimer of Rad18.18
253849752015RAD6 promotes homologous recombination repair by activating the autophagy-mediated degradation of heterochromatin protein HP1.18
288063952017RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance.16
170506672006Essential role of T-cell factor/beta-catenin in regulation of Rad6B: a potential mechanism for Rad6B overexpression in breast cancer cells.14
220839592012RAD6 regulates the dosage of p53 by a combination of transcriptional and posttranscriptional mechanisms.14

Citation

Dessen P

UBE2B (ubiquitin conjugating enzyme E2 B)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42747/ube2b-(ubiquitin-conjugating-enzyme-e2-b)