UBE2D1 (ubiquitin conjugating enzyme E2 D1)

2003-05-01 Affiliation

Identity

HGNC

UBE2D1

LOCATION

10q21.1

LOCUSID

7321

ALIAS

E2(17)KB1,SFT,UBC4/5,UBCH5,UBCH5A

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7321
MIM: 602961
HGNC: 12474
Ensembl: ENSG00000072401

Variants:

dbSNP: 7321
ClinVar: 7321
TCGA: ENSG00000072401
COSMIC: UBE2D1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000072401	ENST00000373910	P51668
ENSG00000072401	ENST00000373910	A0A024QZJ2
ENSG00000072401	ENST00000615793	A0A087WW00

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Ubiquitin mediated proteolysis	KEGG	ko04120
Ubiquitin mediated proteolysis	KEGG	hsa04120
Protein processing in endoplasmic reticulum	KEGG	ko04141
Protein processing in endoplasmic reticulum	KEGG	hsa04141
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
TCR signaling	REACTOME	R-HSA-202403
Downstream TCR signaling	REACTOME	R-HSA-202424
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradation	REACTOME	R-HSA-983168
Innate Immune System	REACTOME	R-HSA-168249
Toll-Like Receptors Cascades	REACTOME	R-HSA-168898
Toll Like Receptor 3 (TLR3) Cascade	REACTOME	R-HSA-168164
MyD88-independent TLR3/TLR4 cascade	REACTOME	R-HSA-166166
TRIF-mediated TLR3/TLR4 signaling	REACTOME	R-HSA-937061
IKK complex recruitment mediated by RIP1	REACTOME	R-HSA-937041
Toll Like Receptor 4 (TLR4) Cascade	REACTOME	R-HSA-166016
Activated TLR4 signalling	REACTOME	R-HSA-166054
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	REACTOME	R-HSA-168928
Negative regulators of RIG-I/MDA5 signaling	REACTOME	R-HSA-936440
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated NF-kB activation	REACTOME	R-HSA-2871837
C-type lectin receptors (CLRs)	REACTOME	R-HSA-5621481
CLEC7A (Dectin-1) signaling	REACTOME	R-HSA-5607764
Signal Transduction	REACTOME	R-HSA-162582
Signaling by BMP	REACTOME	R-HSA-201451
Signaling by TGF-beta Receptor Complex	REACTOME	R-HSA-170834
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	REACTOME	R-HSA-2173793
Downregulation of SMAD2/3:SMAD4 transcriptional activity	REACTOME	R-HSA-2173795
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle Checkpoints	REACTOME	R-HSA-69620
Mitotic Spindle Checkpoint	REACTOME	R-HSA-69618
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	REACTOME	R-HSA-141405
Inactivation of APC/C via direct inhibition of the APC/C complex	REACTOME	R-HSA-141430
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
M Phase	REACTOME	R-HSA-68886
Mitotic Metaphase and Anaphase	REACTOME	R-HSA-2555396
Mitotic Anaphase	REACTOME	R-HSA-68882
Separation of Sister Chromatids	REACTOME	R-HSA-2467813
Regulation of mitotic cell cycle	REACTOME	R-HSA-453276
APC/C-mediated degradation of cell cycle proteins	REACTOME	R-HSA-174143
Regulation of APC/C activators between G1/S and early anaphase	REACTOME	R-HSA-176408
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	REACTOME	R-HSA-176814
Phosphorylation of the APC/C	REACTOME	R-HSA-176412
APC/C:Cdc20 mediated degradation of mitotic proteins	REACTOME	R-HSA-176409
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	REACTOME	R-HSA-179419
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	REACTOME	R-HSA-174184
APC-Cdc20 mediated degradation of Nek2A	REACTOME	R-HSA-179409
APC/C:Cdc20 mediated degradation of Cyclin B	REACTOME	R-HSA-174048
APC/C:Cdc20 mediated degradation of Securin	REACTOME	R-HSA-174154
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	REACTOME	R-HSA-176407
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	REACTOME	R-HSA-174178
Autodegradation of Cdh1 by Cdh1:APC/C	REACTOME	R-HSA-174084
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular response to hypoxia	REACTOME	R-HSA-2262749
Regulation of Hypoxia-inducible Factor (HIF) by oxygen	REACTOME	R-HSA-1234174
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	REACTOME	R-HSA-1234176
Cellular Senescence	REACTOME	R-HSA-2559583
Senescence-Associated Secretory Phenotype (SASP)	REACTOME	R-HSA-2559582
Deubiquitination	REACTOME	R-HSA-5688426
Ovarian tumor domain proteases	REACTOME	R-HSA-5689896
Protein ubiquitination	REACTOME	R-HSA-8852135
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	REACTOME	R-HSA-8866652
E3 ubiquitin ligases ubiquitinate target proteins	REACTOME	R-HSA-8866654

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36820504	2023	B-box1 Domain of MID1 Interacts with the Ube2D1 E2 Enzyme Differently Than RING E3 Ligases.	1
37226882	2023	The E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2D2 regulate VEGFR2 dynamics and endothelial function.	0
36820504	2023	B-box1 Domain of MID1 Interacts with the Ube2D1 E2 Enzyme Differently Than RING E3 Ligases.	1
37226882	2023	The E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2D2 regulate VEGFR2 dynamics and endothelial function.	0
34416429	2022	UBCH5 Family Members Differentially Impact Stabilization of Mutant p53 via RNF128 Iso1 During Barrett's Progression to Esophageal Adenocarcinoma.	2
34416429	2022	UBCH5 Family Members Differentially Impact Stabilization of Mutant p53 via RNF128 Iso1 During Barrett's Progression to Esophageal Adenocarcinoma.	2
33650289	2021	Functional interaction of ubiquitin ligase RNF167 with UBE2D1 and UBE2N promotes ubiquitination of AMPA receptor.	7
33650289	2021	Functional interaction of ubiquitin ligase RNF167 with UBE2D1 and UBE2N promotes ubiquitination of AMPA receptor.	7
32051088	2020	S-Nitrosylation at the active site decreases the ubiquitin-conjugating activity of ubiquitin-conjugating enzyme E2 D1 (UBE2D1), an ERAD-associated protein.	4
32051088	2020	S-Nitrosylation at the active site decreases the ubiquitin-conjugating activity of ubiquitin-conjugating enzyme E2 D1 (UBE2D1), an ERAD-associated protein.	4
29414787	2018	Ubiquitin-conjugating enzyme E2 D1 (Ube2D1) mediates lysine-independent ubiquitination of the E3 ubiquitin ligase March-I.	20
30420903	2018	UBE2D1 RNA Expression Was an Independent Unfavorable Prognostic Indicator in Lung Adenocarcinoma, but Not in Lung Squamous Cell Carcinoma.	13
30482241	2018	Gain of UBE2D1 facilitates hepatocellular carcinoma progression and is associated with DNA damage caused by continuous IL-6.	15
29414787	2018	Ubiquitin-conjugating enzyme E2 D1 (Ube2D1) mediates lysine-independent ubiquitination of the E3 ubiquitin ligase March-I.	20
30420903	2018	UBE2D1 RNA Expression Was an Independent Unfavorable Prognostic Indicator in Lung Adenocarcinoma, but Not in Lung Squamous Cell Carcinoma.	13

Citation

Dessen P

UBE2D1 (ubiquitin conjugating enzyme E2 D1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42748/ube2d1-(ubiquitin-conjugating-enzyme-e2-d1)

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