UBE2D3 (ubiquitin conjugating enzyme E2 D3)

2003-10-01 Affiliation

Identity

HGNC

UBE2D3

LOCATION

4q24

LOCUSID

7323

ALIAS

E2(17)KB3,UBC4/5,UBCH5C

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7323
MIM: 602963
HGNC: 12476
Ensembl: ENSG00000109332

Variants:

dbSNP: 7323
ClinVar: 7323
TCGA: ENSG00000109332
COSMIC: UBE2D3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000109332	ENST00000321805	P61077
ENSG00000109332	ENST00000321805	A0A024RDH2
ENSG00000109332	ENST00000338145	P61077
ENSG00000109332	ENST00000338145	A0A024RDH2
ENSG00000109332	ENST00000343106	P61077
ENSG00000109332	ENST00000349311	P61077
ENSG00000109332	ENST00000349311	A0A024RDH2
ENSG00000109332	ENST00000350435	H9KV45
ENSG00000109332	ENST00000357194	P61077
ENSG00000109332	ENST00000394801	P61077
ENSG00000109332	ENST00000394801	A0A024RDH2
ENSG00000109332	ENST00000394803	P61077
ENSG00000109332	ENST00000394803	A0A024RDH2
ENSG00000109332	ENST00000394804	P61077
ENSG00000109332	ENST00000394804	A0A024RDH2
ENSG00000109332	ENST00000453744	P61077
ENSG00000109332	ENST00000453744	A0A024RDH2
ENSG00000109332	ENST00000502404	D6RAH7
ENSG00000109332	ENST00000502563	D6R9F6
ENSG00000109332	ENST00000502690	D6RIZ3
ENSG00000109332	ENST00000503418	D6R933
ENSG00000109332	ENST00000504211	D6RAH7
ENSG00000109332	ENST00000505207	D6RAH7
ENSG00000109332	ENST00000505307	D6R933
ENSG00000109332	ENST00000507845	D6RAH7
ENSG00000109332	ENST00000508238	D6RA11
ENSG00000109332	ENST00000508249	D6RGD0
ENSG00000109332	ENST00000508476	D6RAW0
ENSG00000109332	ENST00000508635	D6RJB3
ENSG00000109332	ENST00000508974	D6R980
ENSG00000109332	ENST00000510129	D6R9F6
ENSG00000109332	ENST00000514755	D6R933
ENSG00000109332	ENST00000618836	A0A087WY85

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Ubiquitin mediated proteolysis	KEGG	ko04120
Ubiquitin mediated proteolysis	KEGG	hsa04120
Protein processing in endoplasmic reticulum	KEGG	ko04141
Protein processing in endoplasmic reticulum	KEGG	hsa04141
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradation	REACTOME	R-HSA-983168
Innate Immune System	REACTOME	R-HSA-168249
Toll-Like Receptors Cascades	REACTOME	R-HSA-168898
Toll Like Receptor 3 (TLR3) Cascade	REACTOME	R-HSA-168164
MyD88-independent TLR3/TLR4 cascade	REACTOME	R-HSA-166166
TRIF-mediated TLR3/TLR4 signaling	REACTOME	R-HSA-937061
IKK complex recruitment mediated by RIP1	REACTOME	R-HSA-937041
Toll Like Receptor 4 (TLR4) Cascade	REACTOME	R-HSA-166016
Activated TLR4 signalling	REACTOME	R-HSA-166054
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	REACTOME	R-HSA-168928
Negative regulators of RIG-I/MDA5 signaling	REACTOME	R-HSA-936440
Signal Transduction	REACTOME	R-HSA-162582
Signaling by BMP	REACTOME	R-HSA-201451
Signaling by TGF-beta Receptor Complex	REACTOME	R-HSA-170834
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	REACTOME	R-HSA-2173793
Downregulation of SMAD2/3:SMAD4 transcriptional activity	REACTOME	R-HSA-2173795
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular response to hypoxia	REACTOME	R-HSA-2262749
Regulation of Hypoxia-inducible Factor (HIF) by oxygen	REACTOME	R-HSA-1234174
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	REACTOME	R-HSA-1234176
Protein ubiquitination	REACTOME	R-HSA-8852135
E3 ubiquitin ligases ubiquitinate target proteins	REACTOME	R-HSA-8866654

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37059365	2023	Ubiquitinome Profiling Reveals in Vivo UBE2D3 Targets and Implicates UBE2D3 in Protein Quality Control.	1
37059365	2023	Ubiquitinome Profiling Reveals in Vivo UBE2D3 Targets and Implicates UBE2D3 in Protein Quality Control.	1
34416429	2022	UBCH5 Family Members Differentially Impact Stabilization of Mutant p53 via RNF128 Iso1 During Barrett's Progression to Esophageal Adenocarcinoma.	2
34416429	2022	UBCH5 Family Members Differentially Impact Stabilization of Mutant p53 via RNF128 Iso1 During Barrett's Progression to Esophageal Adenocarcinoma.	2
32145025	2020	Evolution of an Amniote-Specific Mechanism for Modulating Ubiquitin Signaling via Phosphoregulation of the E2 Enzyme UBE2D3.	2
32401531	2020	UbcH5 Interacts with Substrates to Participate in Lysine Selection with the E3 Ubiquitin Ligase CHIP.	5
32145025	2020	Evolution of an Amniote-Specific Mechanism for Modulating Ubiquitin Signaling via Phosphoregulation of the E2 Enzyme UBE2D3.	2
32401531	2020	UbcH5 Interacts with Substrates to Participate in Lysine Selection with the E3 Ubiquitin Ligase CHIP.	5
28469175	2017	Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity.	57
28469175	2017	Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity.	57
27105523	2016	UBE2D3 gene overexpression increases radiosensitivity of EC109 esophageal cancer cells in vitro and in vivo.	8
27105523	2016	UBE2D3 gene overexpression increases radiosensitivity of EC109 esophageal cancer cells in vitro and in vivo.	8
26502057	2015	Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair.	65
26502057	2015	Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair.	65
24296361	2014	Gene expression profile in fibroblasts of Huntington's disease patients and controls.	19

Citation

Dessen P

UBE2D3 (ubiquitin conjugating enzyme E2 D3)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/42750/ube2d3-(ubiquitin-conjugating-enzyme-e2-d3)