UHRF2 (ubiquitin like with PHD and ring finger domains 2)

2003-06-01  

Identity

HGNC
UHRF2
LOCATION
9p24.1
LOCUSID
115426
ALIAS
NIRF,RNF107,TDRD23,URF2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 115426
MIM: 615211
HGNC: 12557
Ensembl: ENSG00000147854

Variants:

dbSNP: 115426
ClinVar: 115426
TCGA: ENSG00000147854
COSMIC: UHRF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147854ENST00000276893Q96PU4
ENSG00000147854ENST00000381373B1AL33
ENSG00000147854ENST00000450508A0A0A0MSQ3
ENSG00000147854ENST00000468435Q96PU4

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
348260272022MiR-196a promotes the proliferation and migration of esophageal cancer via the UHRF2/TET2 axis.8
348260272022MiR-196a promotes the proliferation and migration of esophageal cancer via the UHRF2/TET2 axis.8
338483952021UV-induced activation of ATR is mediated by UHRF2.2
338763952021HBx promotes hepatocarcinogenesis by enhancing phosphorylation and blocking ubiquitinylation of UHRF2.3
341113982021UHRF2 commissions the completion of DNA demethylation through allosteric activation by 5hmC and K33-linked ubiquitination of XRCC1.12
341625622021IGF2BP1/UHRF2 Axis Mediated by miR-98-5p to Promote the Proliferation of and Inhibit the Apoptosis of Esophageal Squamous Cell Carcinoma.6
344008802021UHRF2 promotes Hepatocellular Carcinoma Progression by Upregulating ErbB3/Ras/Raf Signaling Pathway.6
338483952021UV-induced activation of ATR is mediated by UHRF2.2
338763952021HBx promotes hepatocarcinogenesis by enhancing phosphorylation and blocking ubiquitinylation of UHRF2.3
341113982021UHRF2 commissions the completion of DNA demethylation through allosteric activation by 5hmC and K33-linked ubiquitination of XRCC1.12
341625622021IGF2BP1/UHRF2 Axis Mediated by miR-98-5p to Promote the Proliferation of and Inhibit the Apoptosis of Esophageal Squamous Cell Carcinoma.6
344008802021UHRF2 promotes Hepatocellular Carcinoma Progression by Upregulating ErbB3/Ras/Raf Signaling Pathway.6
323724482020UHRF2 promotes intestinal tumorigenesis through stabilization of TCF4 mediated Wnt/β-catenin signaling.13
323724482020UHRF2 promotes intestinal tumorigenesis through stabilization of TCF4 mediated Wnt/β-catenin signaling.13
295061312018Comparative biochemical analysis of UHRF proteins reveals molecular mechanisms that uncouple UHRF2 from DNA methylation maintenance.18

Citation

Dessen P

UHRF2 (ubiquitin like with PHD and ring finger domains 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42765/uhrf2-(ubiquitin-like-with-phd-and-ring-finger-domains-2)