ASAP3 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 3)

2003-05-01  

Identity

HGNC
LOCATION
1p36.12
LOCUSID
ALIAS
ACAP4,CENTB6,DDEFL1,UPLC1
FUSION GENES

Other Information

Locus ID:

NCBI: 55616
MIM: 616594
HGNC: 14987
Ensembl: ENSG00000088280

Variants:

dbSNP: 55616
ClinVar: 55616
TCGA: ENSG00000088280
COSMIC: ASAP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000088280ENST00000336689Q8TDY4
ENSG00000088280ENST00000336689A0A024RAB1
ENSG00000088280ENST00000437606Q8TDY4
ENSG00000088280ENST00000465372H0YEB0
ENSG00000088280ENST00000475814H0YER8
ENSG00000088280ENST00000484418H0YE36
ENSG00000088280ENST00000492982E9PS98
ENSG00000088280ENST00000495646Q8TDY4
ENSG00000088280ENST00000608765V9GY49
ENSG00000088280ENST00000618240A0A087X0Y5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
184007622008ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion.33
205109282010The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism.28
167379522006Proteomic identification and functional characterization of a novel ARF6 GTPase-activating protein, ACAP4.24
220278262011ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin β1 recycling in cell migration.12
240784472014ASAP3 expression in non-small cell lung cancer: association with cancer development and patients' clinical outcome.9
242846542014Loss of ASAP3 destabilizes cytoskeletal protein ACTG1 to suppress cancer cell migration.9
237762072013Phosphorylation of the Bin, Amphiphysin, and RSV161/167 (BAR) domain of ACAP4 regulates membrane tubulation.8
305369962019MicroRNA-143-3p inhibits colorectal cancer metastases by targeting ITGA6 and ASAP3.8
285021112017Upregulation of ASAP3 contributes to colorectal carcinogenesis and indicates poor survival outcome.4
303952692018Acetylation of ACAP4 regulates CCL18-elicited breast cancer cell migration and invasion.2

Citation

Dessen P

ASAP3 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42769/asap3-(arfgap-with-sh3-domain-ankyrin-repeat-and-ph-domain-3)