HUWE1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1)

2003-06-01 Affiliation

Identity

HGNC

HUWE1

LOCATION

Xp11.22

LOCUSID

10075

ALIAS

ARF-BP1,HECTH9,HSPC272,Ib772,LASU1,MRXST,MULE,URE-B1,UREB1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10075
MIM: 300697
HGNC: 30892
Ensembl: ENSG00000086758

Variants:

dbSNP: 10075
ClinVar: 10075
TCGA: ENSG00000086758
COSMIC: HUWE1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000086758	ENST00000262854	Q7Z6Z7
ENSG00000086758	ENST00000262854	A0A024R9W5
ENSG00000086758	ENST00000342160	Q7Z6Z7
ENSG00000086758	ENST00000342160	A0A024R9W5
ENSG00000086758	ENST00000426907	H0Y659
ENSG00000086758	ENST00000446750	A0A1B0GXC7
ENSG00000086758	ENST00000468322	A0A087X146
ENSG00000086758	ENST00000612484	Q7Z6Z7
ENSG00000086758	ENST00000612484	A0A024R9U8
ENSG00000086758	ENST00000622887	A0A087X1S3

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Ubiquitin mediated proteolysis	KEGG	ko04120
Ubiquitin mediated proteolysis	KEGG	hsa04120
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradation	REACTOME	R-HSA-983168
Innate Immune System	REACTOME	R-HSA-168249
Neutrophil degranulation	REACTOME	R-HSA-6798695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
15989957	2005	Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis.	332
15989957	2005	Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis.	332
15989956	2005	ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor.	202
15989956	2005	ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor.	202
16269333	2005	The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation.	137
18488021	2008	The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein.	110
18252223	2008	Submicroscopic duplications of the hydroxysteroid dehydrogenase HSD17B10 and the E3 ubiquitin ligase HUWE1 are associated with mental retardation.	68
17567951	2007	Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage.	62
19713937	2009	Ubiquitin ligase ARF-BP1/Mule modulates base excision repair.	62
20534529	2010	E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alpha.	43

Citation

Dessen P

HUWE1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42770/huwe1-(hect-uba-and-wwe-domain-containing-e3-ubiquitin-protein-ligase-1)