USP5 (ubiquitin specific peptidase 5)

2003-11-01  

Identity

HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
ISOT
FUSION GENES

Other Information

Locus ID:

NCBI: 8078
MIM: 601447
HGNC: 12628
Ensembl: ENSG00000111667

Variants:

dbSNP: 8078
ClinVar: 8078
TCGA: ENSG00000111667
COSMIC: USP5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111667ENST00000229268P45974
ENSG00000111667ENST00000229268A0A140VJZ1
ENSG00000111667ENST00000389231P45974
ENSG00000111667ENST00000542087F5H571

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880
Protein ubiquitinationREACTOMER-HSA-8852135
Synthesis of active ubiquitin: roles of E1 and E2 enzymesREACTOMER-HSA-8866652

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
380490412024USP5: Comprehensive insights into structure, function, biological and disease-related implications, and emerging therapeutic opportunities.1
382170302024PFKP deubiquitination and stabilization by USP5 activate aerobic glycolysis to promote triple-negative breast cancer progression.0
382188982024Ubiquitin-specific protease 5 promotes bladder cancer progression through stabilizing Twist1.1
386925072024The deubiquitinase USP5 promotes cholangiocarcinoma progression by stabilizing YBX1.0
380490412024USP5: Comprehensive insights into structure, function, biological and disease-related implications, and emerging therapeutic opportunities.1
382170302024PFKP deubiquitination and stabilization by USP5 activate aerobic glycolysis to promote triple-negative breast cancer progression.0
382188982024Ubiquitin-specific protease 5 promotes bladder cancer progression through stabilizing Twist1.1
386925072024The deubiquitinase USP5 promotes cholangiocarcinoma progression by stabilizing YBX1.0
349531002023Role of ubiquitin-specific protease 5 in the inflammatory response of chronic periodontitis.3
363292252023Kawasaki disease: ubiquitin-specific protease 5 promotes endothelial inflammation via TNFα-mediated signaling.3
372686972023A pan-cancer analysis of the role of USP5 in human cancers.0
375349342023USP5 promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein.2
376422352023DEPDC1B-mediated USP5 deubiquitination of β-catenin promotes breast cancer metastasis by activating the wnt/β-catenin pathway.1
349531002023Role of ubiquitin-specific protease 5 in the inflammatory response of chronic periodontitis.3
363292252023Kawasaki disease: ubiquitin-specific protease 5 promotes endothelial inflammation via TNFα-mediated signaling.3

Citation

Dessen P

USP5 (ubiquitin specific peptidase 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42772/usp5-(ubiquitin-specific-peptidase-5)