UXT (ubiquitously expressed prefoldin like chaperone)

2003-06-01  

Identity

HGNC
UXT
LOCATION
Xp11.23
LOCUSID
8409
ALIAS
ART-27,STAP1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8409
MIM: 300234
HGNC: 12641
Ensembl: ENSG00000126756

Variants:

dbSNP: 8409
ClinVar: 8409
TCGA: ENSG00000126756
COSMIC: UXT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126756ENST00000333119Q9UBK9
ENSG00000126756ENST00000335890Q9UBK9
ENSG00000126756ENST00000485641S4R2Z4

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
374681052023MYB regulates the SUMO protease SENP1 and its novel interaction partner UXT, modulating MYB target genes and the SUMO landscape.1
374681052023MYB regulates the SUMO protease SENP1 and its novel interaction partner UXT, modulating MYB target genes and the SUMO landscape.1
347679642022HOXD9 transcriptionally induced UXT facilitate breast cancer progression via epigenetic modification of RND3.2
352172672022Prefoldin and prefoldin-like complex subunits as predictive biomarkers for hepatocellular carcinoma immunotherapy.2
347679642022HOXD9 transcriptionally induced UXT facilitate breast cancer progression via epigenetic modification of RND3.2
352172672022Prefoldin and prefoldin-like complex subunits as predictive biomarkers for hepatocellular carcinoma immunotherapy.2
327441192021Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation.6
330103522021The E3 ubiquitin ligase SCF(Fbxo7) mediates proteasomal degradation of UXT isoform 2 (UXT-V2) to inhibit the NF-κB signaling pathway.7
337824102021UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy.6
327441192021Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation.6
330103522021The E3 ubiquitin ligase SCF(Fbxo7) mediates proteasomal degradation of UXT isoform 2 (UXT-V2) to inhibit the NF-κB signaling pathway.7
337824102021UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy.6
314810812019Ubiquitous expressed transcript promotes tumorigenesis by acting as a positive modulator of the polycomb repressive complex 2 in clear cell renal cell carcinoma.4
314810812019Ubiquitous expressed transcript promotes tumorigenesis by acting as a positive modulator of the polycomb repressive complex 2 in clear cell renal cell carcinoma.4
281063012017UXT Is a LOX-PP Interacting Protein That Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells.13

Citation

Dessen P

UXT (ubiquitously expressed prefoldin like chaperone)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42779/uxt-(ubiquitously-expressed-prefoldin-like-chaperone)